Nose Jobs, Eyelid Surgery, Liposculpture, Face Lift, Chest Contour Surgery, Gynecomastia Surgery, Chin Implants, Alternative Plastic Surgery Procedures, Ear Surgery, Hair Transplantation, Tummy Tuck, Skin Care for Men, Men's Issues, Men's Health and Fitness
Men with a long ring finger could be three times more likely to develop prostate cancer, research shows.
Doctors found that the risk increases if the ring finger on the right hand is significantly longer than the index finger next to the thumb. But men whose ring fingers are only slightly longer, or are about the same length, are much less likely to get the disease.
The findings open up the possibility of screening men with longer fingers at an early age for signs of cancer.
In the study, blood tests showed that men with longer ring fingers on their right hand had higher levels of prostate specific antigen (PSA).
This chemical is sometimes found in high levels in blood when cancer is present. The right hand was studied because the difference between the length of its ring finger and index finger is often greater than on the left, as it is more sensitive to hormonal changes in the womb. The results are the latest in a long line of studies linking finger length to men's health, most of which highlight the benefits of a long ring finger.
These include reduced risk of heart disease, a better chance of exam success and increased fertility.
Last year a team of experts from the Medical Research Council's Epidemiology Resource Unit at Southampton University even found that young men with longer ring fingers made better sprinters.
The key to these findings is thought to be the level of exposure to the hormone testosterone in the womb.
Higher levels also make it more likely that a boy will have a slightly longer ring finger on their right hand. Testosterone is also known to stimulate prostate tumour development.
In the latest study, doctors at Gachon University Gil Hospital, in Incheon, South Korea, studied 366 men over the age of 40 who went to a hospital clinic complaining of problems urinating, a symptom which could be a warning sign of cancer.
They had their fingers measured from the crease where the finger joins the hand to the tip.
Blood tests showed that men with much longer ring fingers had almost double the levels of PSA found in the blood of those with shorter fingers.
Three times as many of these men went on to be diagnosed with prostate cancer. Researchers writing in the British Journal of Urology online said the 'digit ratio' - the difference in length between ring and index finger - could be used to predict which men could get cancer.
'Digit ratio is a predictor of high PSA levels and the presence of prostate cancer,' they said.
'We believe our results present sufficient evidence that a relationship exists between the two.'
Nearly 32,000 cases of prostate cancer are diagnosed a year in the UK and 10,000 men die from it - more than one an hour.
But Ed Yong, Cancer Research UK's head of health information, said: 'Finger length ratios have been linked to all sorts of things before with little evidence that measuring these ratios will ever actually be useful.
'For example, this very small study finds an association between finger length ratio and prostate cancer risk, but tells us nothing about whether the ratio can be used to reliably predict that risk.'
If you are considering a facelift but hesitate due to the recovery period from the surgery you may be a candidate for a microcurrent facelift. What is a microcurrent facelift? It is a non-surgical, non-invasive plastic surgery that is safe and efficiently improve the appearance of the skin. Also known as a Bio-ultimate facelift, the microcurrent facelift uses technologies developed in the medical and physiotherapy fields to activate the skin’s natural chemical response for health and vitality. It is safer than the traditional facelift with fewer side effects and at a fraction of the cost.
A microcurrent facelift benefits the patients by helping them attain a healthier, younger looking appearance which improves muscle tone in the face, neck, jowls, eyebrows while reducing fine lines and wrinkles, improve facial circulation, skin exfoliation, lymphatic drainage, sun damage, age spots, acne scars and more. It uses gentle electrical stimulation to trigger the skin’s cellular level. Clinical studies have shown that after twenty days of treatment collagen production increases by 14%, elastin by 48% and blood circulation by 38% all the while producing amino acids and ATP that accelerate cell repair and promote cell production. The microcurrent treatment works by applying gentle electric stimulation to the surface of the skin using fine dual prongs applied to various regions of the face.
Despite what you might think – it’s not at all painful. You may experience slight tingling but most people find it relaxing and many actually fall asleep. This procedure isn’t new as it was originally developed to treat those with facial palsy and in sports medicine. They discovered the visual improvements to the tone and texture of the skin and it became apparent that it could also be used for the cosmetic industry.
The best candidate for a microcurrent facelift is anyone that wants a younger, youthful appearance. Younger clients can seek a microcurrent facelift to prevent some of the aesthetic effects of aging and older patients can find their skin rejuvenated. If you are interested in having a microcurrent facelift, you should speak to your doctor or dermatologist so that he can recommend a qualified cosmetic surgery. An initial consultation is recommended to review the benefits and what is expected before, during and after the treatment. This information will help you develop realistic expectations about the results from the procedure.
The microcurrent facelift procedure itself takes approximately one hour to complete and is virtually painless. A microcurrent facelift specialist will use a two pronged cotton tipped instrument to gently deliver electrical stimulation to the muscles and tissues of the face and/or neck. The microcurrent facelift procedure requires no anesthesia, no recovery time, no down time from work, and has no irritating side effects. Most people need a course of around 10 microcurrent sessions to see the full benefits – although many claim to see immediate results from the first treatment. The exact number you need will depend on your skin tissue and muscle tone – not necessarily on your age.
After the initial course of microcurrent treatments, you only need to return for a booster treatment on average around every 4-6 weeks. If you don’t follow the maintenance plan – you’ll lose the improvements in tone, radiance and lift.
You can expect to pay around $100 for one session which will last an hour so your initial course of 10 sessions will come in at $1000 or so depending on the cosmetic surgery center location.
Obviously this isn’t a small amount of money but compared with facial cosmetic surgery a course of microcurrent treatments is great value. And you won’t need to spend the $1000 all over again five years down the line. Provided you stick with a maintenance schedule your results will last – unlike facial cosmetic surgery or other types of non surgical face lift which need to be repeated as improvements are lost over time.
And if you don’t want to spend so much – consider a home hand held microcurrent device. The NuFace Microcurrent Skin Toning Device is available on Amazon.com as well as other online websites.
Amazon Product Description
NuFace Microcurrent Skin Toning Device is the first FDA approved anti aging skin care product for facial toning. Use the NuFace microcurrent facial machine daily to enhance the natural beauty of your face and skin without plastic surgery! Unlike other anti aging and facial toning products that consist of a large microcurrent facial machine with wires and probes, the NuFace Microcurrent Skin Toning Device consists of a hand held, enclosed unit without any wires.
The NuFace Microcurrent System uses safe, painless, low-level, waveform-shaped currents (electrical impulses) to "reprogram" the muscles to almost original muscle shape. The electrical impulses rehabilitate the muscles and improve circulation, texture, tone, and fine lines. Use the NuFace Microcurrent Skin Toning Device for facial toning and anti aging regularly to continue to provide muscle strength and restore freshness to appearance.
Is NuFace® cleared by the FDA?
Yes, the spa-quality NuFace® device we offer is cleared by the FDA as a Class II Medical Device that is safe and effective for at-home personal use. It safely and effectively improves the appearance of the face and body through the use of microcurrent technology. The muscles and skin tissues are lifted and toned utilizing the NuFace’s non-invasive and gentle electrical stimulation. “The NuFace® device is bringing anti-aging to the next level. Where Botox has made the anti-aging market turn on its heels, the micro-current NuFace® device is a new and innovative skin health product,” says Dr. Peter Pugliese.
How Does the NuFace® device work? This non-invasive approach to facial rejuvenation can be used just 5 minutes a day to improve improve muscle tone in the face and neck. Simply glide the NuFace® device along the contour of the face (as shown in the video you will receive with your unit) while a gentle alternating current is emitted through dual spherical probes. The intensity level is adjustable.
On the first day, God created woman, on the second day came Man and some time during the afternoon of the sixth, allowing His mind to wander, He created male nipples. Well, not quite, but as Brian Charlesworth, professor of evolutionary biology at Edinburgh University explains, male nips are a bit of a Darwanian afterthought.
Breasts and nipples have evolved in mammals to allow mothers to provide milk to their young. Male mammals rarely care for their offspring and so have no need for them. The evolution of these structures involved developmental changes that are hard to restrict to just females, because the genes responsible are present in both sexes.
Originally, breasts and nipples may well have been present in both male and female mammals—100 or so million years ago. There may have been natural selection to reduce their size in males since there would be possible harmful side effects of their presence (increased susceptibility to cancer).
They simply have not been completely eliminated. Think of your nipples like your appendix. That’s still no reason to remove them, mind you!
I found blood in my semen. Is it serious?
- Gagan Sethi, New Delhi
Calm down, it’s a routine plumbing problem. “One in 100 men experience this condition, known as haematospermia and it’s usually nothing to worry about,” says Dr Kapil Juneja, a consultant urologist, Moolchand Medcity, New Delhi. “The cause is likely to be harmless infl ammation of your prostate or seminal vesicles, however, you should get it examined to rule out infection and bleeding disorders.” Haematospermia usually goes away on its own after about a month, although 25 per cent of men will probably experience it again. (Urologists aren’t sure why.)
If it persists for three months, or if you’re 40 or older, see your doctor for a PSA test. It could be something more serious; prostate cancer accounts for about 2 per cent of haematospermia cases. Follow doctor’s orders—they can be fun. “Ejaculating at least once a week improves your urologic health, decreasing the chances of haematospermia,” says Dr Juneja.
Why do I talk in my sleep?
- Shantanu Behel, Bangalore
Think of it as a kind of a brain fart. “Your sleeping brain is actually very active, but it doesn’t have a censor, so random words can come out of your mouth,” explains sleep disorder specialist Dr Manvir Bhatia, Sir Gangaram Hospital, New Delhi. “Often the content is just refl ective of your brain’s sleep activity and it can be words, sentences or gibberish.”
If your unconscious utterings are bothering your bedmate, cut back on your evening alcohol and try to find ways to lower your stress level. Both booze and chronic tension can disturb your sleep patterns and that in turn may amplify your verbal outbursts.
Just one word of caution: “If your pillow talk becomes frequent, prolonged or increases in volume or profanity, see your doctor ASAP,” says Dr Bhatia. Any one of these changes could signal that you’re suffering from a sleep condition, such as sleep apnoea, nocturnal seizures or REM sleep behaviour disorder (the acting out of dreams with yelling, punching and jumping out of bed).
How can I get more defi nition in my biceps? I want those veins to pop.
- Gaurav Gill, Hyderabad
Don’t think about building the biceps. Weight lifting won’t make your veins any bigger. To get a bulge in that cephalic vein (that’s the one that runs over your biceps), you’re battling a tag team of genetics and flab. Since you can’t do anything about your genes, aim for less than 10 per cent body fat, suggests Micheal Mejia, CSCS, a Men’s Health exercise advisor. Focus on exercises that work large muscle groups and do high-repetition sets with little rest in between. Try this variation on the clean and press.
Stand with your feet shoulder-width apart and hold a pair of dumbbells with your palms facing your hips
1. Bend your knees and drop into a squat position
2. Letting the dumbbells come to rest on the floor. Make sure your back is straight and your knees don’t extend beyond your toes. In one move, kick your legs back, letting your weight rest on the dumbbells and your toes, as if in a pushup position
3. Reverse the move and stand, pressing the dumbbells overhead
4. Do two or three sets of six to 10 repetitions, resting for 60 to 90 seconds in between.
US News and World Report: Having a few more cups of coffee and running that extra mile each day can reduce a man's risk of dying of prostate cancer, two studies indicate.
The case for coffee and physical activity as prostate cancer preventatives is far from proven, according to the research reported Tuesday at an American Association for Cancer Research meeting in Houston. But data from the Health Professionals Follow-Up Study show a clear association with both daily activities.
"I wouldn't recommend that people change their coffee-drinking habits based on this study," said Kathryn M. Wilson, a research fellow in epidemiology at the Harvard School of Public Health, and lead author of one report. "But if you like coffee, there is no compelling reason to cut back at this point."
Her data on the nearly 50,000 men in the study showed how common a diagnosis of prostate cancer has become since widespread screening began. In the 20 years from 1986 to 2006, 4,975 cases of prostate cancer were diagnosed, affecting just about 10 percent of the men in the study.
But only 846 of those cancers were life-threatening, because they had spread beyond the prostate gland or were growing aggressively, Wilson said. And while the study found just a weak relationship between consumption of six or more cups of coffee a day and a reduced risk of all forms of prostate cancer (down about 19 percent), the reduction for the aggressive form was much more marked -- 41 percent.
And there was a clear relationship between the amount of coffee consumed and prostate cancer risk, Wilson said: "The more coffee you drank, the more effect we saw."
The caffeine in coffee doesn't seem to be the link, since the same reduction was seen for consumption of decaffeinated coffee, she said. Instead, "it has something to do with insulin and glucose metabolism," Wilson said. "A number of studies have found that coffee is associated with a reduced risk of diabetes."
This study is just a starting point for establishing a relationship between coffee and prostate cancer, Wilson stressed. "At this point, we would just like to confirm whether it exists in different populations," she said. "We hope that this study drives more research so that we really know what is going on."
The other study, by Stacey A. Kenfield, a research associate at the Harvard School of Public Health, looked at the levels of physical activity among 2,686 men in the study who were diagnosed with prostate cancer. It found, as many other studies have, that exercise is good for overall health, with a 35 percent lower death rate for men who reported three or more hours a week of vigorous physical activity, such as jogging, biking, swimming or playing tennis.
And the death rate from prostate cancer for men who exercised vigorously was 12 percent lower than for those who didn't -- a figure that did not quite reach the level of statistical significance because the numbers were small, Kenfield explained.
Nevertheless, "this is the first study to show an effect of physical activity not only on overall survival, but on prostate cancer survival," she said.
It's already well known how physical activity reduces overall mortality, Kenfield said. "It affects immune function and reduces inflammation, among the major processes involved. But it's not clear yet how it is related to prostate cancer and survival."
I love a well-dressed man; who doesn't? It's so refreshing to see a stylish man during the summer amongst the sea of baggy cargo shorts and sweaty wifebeaters, and so in an effort to eradicate this male fashion travesty, I've put together a handy guide for men to help you fashionistos look top-notch in summer 2010. Below are my shopping picks as well as six suggestions for how to wear them.
1) Start simple with a clean, simple, and lightweight white shirt; you can build many looks from this summer staple. As I said previously, orange is the hottest spring/summer trend for men, and so I highly recommend incorporating it into your look. Pair the white shirt with some flat-front orange shorts.
2) To dress it up, add a navy blazer with orange cuffs as an eyecatching accent. From there, warm-weather basics like Ray Bans and boat shoes (try navy for a nautical look) will complete the look.
3) If you want to wear the orange shorts but go more casual, try an interesting graphic tee and go sans-blazer. Still pair with boatshoes; don't give in to wearing mandals!
4) For a sophisticated white-out look, pair the white shirt with some white-wash jeans and add a seersucker tie to bring some attitude. Again, the navy Sperry's will look great, and donning shades is a must.
5) To continue with the orange theme, buy a basic orange crew-neck shirt. You can wear this with the white-wash jeans or khaki shorts, and adding a navy blazer and some nautical anchor cufflinks will allow you to dress up this look.
6) The last look I recommend is wearing the basic orange crew-neck and wearing the white shirt open over it. Pair with the white jeans or khaki shorts, shades, and boat shoes to have a classy but casual look.
As you can see, with the right basics the possibilities for great men's summer style are endless. Find what look suits your style best and prove that you can be a fashionisto even in hot, sticky weather.
or its generic version Dapoxetine which is the first
pill form medication designed purposely to treat
premature ejaculation (PE) in men. Premature ejaculation, being defined as ejaculating quicker than their partner or themselves would desire. Technically Dapoxetine or Priligy® is what is known as a SSRI
(selective serotonin reuptake inhibitor). SSRI's are typically prescribed for patients that experience depression and as such are used as antidepressants. However some SSRI's have shown the ability to reduce ejaculation time in some men but no other SSRI in studies has worked as well as
Dapoxetine for this issue.
Apparently it is also safer and eliminated from the body quicker than typical SSRI's as its terminal half life is approximately 20 hours with its initial half life around 1.4 hours. This is partially why it was rejected as a depression treatment. Because of its short duration a patient would need to be taking this medication several times per day for a proper effect, which is fairly unrealistic and as such Dapoxetine has not been actually approved as an antidepressant.
Simply put this drug instructs the brain to delay ejaculation. It also does not change the sensitivity of the male sexual organs. Some products have been created that numb this area but get very mixed and often negative reviews. Priligy®/Dapoxetine is not considered a permanent cure for premature ejaculation but when it is taken approximately three hours before sexual activity it can work very well. Studies show it can work in up to seventy percent of men facing this problem and has shown to postpone ejaculation by upwards of three times.
In a study, when men took 30mg of Priligy®/Dapoxetine they increased to ejaculation from 1 minute 45 seconds to just over 2 minutes 45 seconds. The men, who received 60mg of the drug, lasted just over 3 minutes thirty seconds. In a further study with around 2600 patients the researchers found that this medication increased the time a man could last upwards between 3 to 5 times their normal. Results would vary for each individual but averages definitely show a very large improvement much to the delight of both its users and manufacturers. They also determined that this may safely be taken by men between the ages of 18 to 64 provided that they are healthy enough for sex to begin with.
Priligy® / Dapoxetine has been approved for premature ejaculation in several European countries with more expected to approve it soon. Some of the countries where it is approved are Sweden, Germany, Spain, Portugal, Finland, Austria, Italy, sources say that it is now available in the UK and other countries both in Europe and other continents are expected to soon have it available. However at the time of this writing the FDA has not yet approved it for the United States. It currently is in phase three trial investigations and testing but expect to hear something soon regarding its possibility in the US.
Premature ejaculation although not a dangerous or necessarily unhealthy condition, can cause disappointment, irritation, embarrassing as well as a relationship barrier to both partners. Numbers worldwide pin this problem somewhere around thirty percent but it is a little difficult to quantify as most men do not want to talk about it and it is hard to exclusively define. Some men who normally would not be under the premature ejaculation banner may from time to time in their life experience times of it. This can be brought on from over excitement or forms of anxiety.
Treating PE can be accomplished through various exercises performed along with mental imagery and other psychological practices but now there is a medical way to fight this issue. If you live in a country where Dapoxetine / Priligy® if available and you are interested in trying it, we would suggest you visit your doctor for their view of you taking it as well as any concerns or questions.
F.A.Q. (Frequently Asked Questions)
Composed below are some questions some people may have regarding Dapoxetine / Priligy®
Q) What are the side effects of this medication?
A) Side effects can be, but not limited to, nausea, dizziness, diarrhea, headache, tiredness. But these are not necessarily what you will experience, some experience all, some or none and to different degrees, but mostly mild to moderate. Always consult your doctor or pharmacist if others appear or if you have any questions what so ever.
Q) I am ready take a SSRI for depression, can I take this?
A) Generally No, Dapoxetine / Priligy ® should not be taken if you are on any other SSRI drug or drugs with serotonergic effects such as migraine drugs. Also do not take if you have heart problems or are dehydrated. Talk to your doctor.
Q) Can I drink Alcohol and take this medication?
A) No, you should not have this drug with alcohol. This can be dangerous.
Q) How often can I take this?
A) If you have been approved to take it, it generally should only be taken once in a 24 hour period.
Q) Are there age limits with this?
A) You should not use this product if you are under the age of 18 or over 64. Some exceptions may be made by your doctor.
Q) Can one take a drug such as Viagra or Cialis or Levitra (a PDE5 inhibitor) with this?
A) Studies show that these can be taken together. But always talk to your doctor as there could be other reasons not for someone to combine any medications together.
resource:http://www.dapoxetinepills.com/
Although this article refers to men staring at the tube, watching Dancing with the Stars (right) and driving in a car for more than 23 hours a week, this probably affects those that sit in from of their computers at home searching the web, chatting or talking to friends on Facebook.
In 1982, researchers affiliated with the Cooper Institute in Dallas surveyed a large group of well-educated, affluent men. The researchers were interested in the men’s exercise habits, but they also asked, almost incidentally, about their indolence. Specifically, they inquired about how many hours each day the men spent watching television or sitting in a car. (This was before you could do both at once.) Over the years, the survey’s main results were used to reinforce a growing body of science about the health benefits of regular exercise.
But the information about the amount of time the men spent being inactive remained largely unexplored. Recently, however, scientists from the University of South Carolina and the Pennington Biomedical Research Center in Baton Rouge, La., parsed the full data. In a study published in May in the journal Medicine and Science in Sports and Exercise, they reported that, to no one’s surprise, the men who sat the most had the greatest risk of heart problems. Men who spent more than 23 hours a week watching TV and sitting in their cars (as passengers or as drivers) had a 64 percent greater chance of dying from heart disease than those who sat for 11 hours a week or less. What was unexpected was that many of the men who sat long hours and developed heart problems also exercised. Quite a few of them said they did so regularly and led active lifestyles. The men worked out, then sat in cars and in front of televisions for hours, and their risk of heart disease soared, despite the exercise. Their workouts did not counteract the ill effects of sitting.
Most of us have heard that sitting is unhealthy. But many of us also have discounted the warnings, since we spend our lunch hours conscientiously visiting the gym. We consider ourselves sufficiently active. But then we drive back to the office, settle at our desks and sit for the rest of the day. We are, in a phrase adopted by physiologists, ‘‘active couch potatoes.’’
The amount of time that most Americans spend being inactive has risen steadily in recent decades. A 2009 editorial in the British Journal of Sports Medicine reported that, on average, adults spend more than nine hours a day in oxymoronic ‘‘sedentary activities.’’ For studies like these, scientists categorize activities by the number of METs they demand. A MET, or metabolic equivalent of task, is a measure of energy, with one MET being the amount of energy you burn lying down for one minute. Sedentary behaviors demand one to one and a half METs, or very little exertion.
Decades ago, before the advent of computers, plasma TVs and Roombas, people spent more time completing ‘‘light-intensity activities,’’ which require between one and a half and three METs. Most ‘‘home activities,’’ like mopping, cooking and changing light bulbs, demand between two and three METs. (One exception is ‘‘butchering animals,’’ a six-MET activity, according to a bogglingly comprehensive compilation from 2000 of the METs associated with different activities.) Nowadays, few of us accumulate much light-intensity activity. We’ve replaced those hours with sitting.
The physiological consequences are only slowly being untangled. In a number of recent animal studies, when rats or mice were not allowed to amble normally around in their cages, they rapidly developed unhealthy cellular changes in their muscles. The animals showed signs of insulin resistance and had higher levels of fatty acids in their blood. Scientists believe the changes are caused by a lack of muscular contractions. If you sit for long hours, you experience no ‘‘isometric contraction of the antigravity (postural) muscles,’’ according to an overview of the consequences of inactivity published this month in Exercise and Sports Sciences Reviews. Your muscles, unused for hours at a time, change in subtle fashion, and as a result, your risk for heart disease, diabetes and other diseases can rise.
Regular workout sessions do not appear to fully undo the effects of prolonged sitting. ‘‘There seem to be different pathways’’ involved in the beneficial physiological effects of exercising and the deleterious impacts of sitting, says Tatiana Warren, a graduate student in exercise science at the University of South Carolina and the lead author of the study of men who sat too much. ‘‘One does not undo the other,’’ she says.
You can, however, ameliorate the dangers of inactivity with several easy steps — actual steps. ‘‘Look for ways to decrease physical inactivity,’’ Ms. Warren says, beyond 30-minute bouts of jogging or structured exercise. Stand up. Pace around your office. Get off the couch and grab a mop or change a light bulb the next time you watch ‘‘Dancing With the Stars.’’
resource: http://well.blogs.nytimes.com/2010/07/14/phys-ed-the-men-who-stare-at-screens/?apage=1
Baldness is probably the one thing that causes men more anxiety than anything else in their life. Now, scientists believe they may have found a new way to reverse baldness and treat conditions like alopecia.
Scientists have identified stem cells or master cells in the hair follicles of mice. They found that these cells grow into hair follicles and produce hair when transplanted into skin. George Cotsarelis, Assistant Professor of dermatology from the University of Pennsylvania, said that the study could lead to new ways of treating hair loss in humans through drugs or surgery.
"This may lead to a new type of tissue engineering for treating baldness - for example, isolating hair follicle stem cells from the scalp and reconstituting hair follicles in bald areas," Dr Cotsarelis said. "I can't predict the future but this type of research certainly opens new avenues for developing new treatments for baldness."
The study, published in the journal Nature Biotechnology, isolated the stem cells within the bulbous follicle at the base of a hair shaft. Sometimes these follicles go into a permanent resting phase, halting hair regeneration. When the researchers transplanted the stem cells into the skin of other mice, hair follicles began to re-grow within four weeks.
"Now that we can isolate stem cells involved in hair growth, we can develop targets for manipulating hair growth," Dr Cotsarelis said.
Receding hairlines and the arrival of the bald patch are feared by men around the globe. Hair may start to disappear from the temples and the crown of the head at any time. For some men this process starts as early as the later teenage years, for most it happens in the late 20s and early 30s. Initially it may just be a little thinning that's noticed. Then, the absence of hair allows more of the scalp to become visible.
Some men are not troubled by this process at all. Others, however, suffer great emotional distress associated with a lack of self-confidence and sometimes depression.
In male pattern baldness, which is hereditary, the hair is usually lost at the temples and the crown. This happens because an over-sensitivity of the hair follicle to normal levels of testosterone switches the hair loss gene on. Not every hair follicle has this gene which is why some hair falls out whilst other hair doesn't. Other causes of hair-loss that are usually reversible include; iron deficiency anaemia; under-active thyroid; fungal scalp infection; some prescribed medicines; and stress.
Scientists have long-suspected that hair follicles contained stem cells. However, it has proved difficult to isolate these cells in humans. This latest study raises hopes that they can now track these genes and identify stem cells in human hair follicles. "Ultimately, these findings provide potential targets for the treatment of hair loss and other disorders of skin and hair," the researchers wrote.
While the discovery could lead to new treatments for baldness and conditions like alopecia, the researchers believe it may also help burn victims. "One problem with a burn is that the wound is never covered with hair follicles," said Dr Cotsarelis. "These cells have that capability so if we can isolate them and seed them onto a wound we can constitute skin that is more normal than currently possible."
Hair multiplication
Stem cells and dermal papilla cells have been discovered in hair follicles and some researchers predict research on these follicular cells may lead to successes in treating baldness through hair multiplication (HM), also called hair cloning.
HM is being developed by ARI (Aderans Research Institute, a Japanese owned company in the USA).
In 2008, Intercytex, a company in Manchester (UK), announced positive results of a Phase II trial for a form of cloning hair follicles from the back of the neck, multiplying them and then reimplanting the cells into the scalp. The initial testing resulted in at least two thirds of male patients regrowing hair. As of 2009, the company estimates this treatment will take "a number of years to complete" Phase III trials before it can go to market.
However, after failing to achieve subsequent success in their trials, the company announced discontinuation of its hair multiplication project in January 2010 with intention to sell off its assets and research.[30] In March 25, 2010 Aderans Research Institute Inc. (ARI) announced it acquired key technology assets from Regenerative Medicine Assets Limited (formerly
In May 2007, U.S. company Follica Inc, announced they have licensed technology from the University of Pennsylvania which can regenerate hair follicles by reawakening genes which were once active only in the embryo stage of human development. Skin apparently can be brought back to this embryonic state when a wound is healing. Hair growth was discovered in the skin wounds of mice when Wnt proteins were introduced to the site. Development of a human treatment is expected to take several years.
resource: http://en.wikipedia.org/wiki/Baldness_treatments
In other news:
New Clinically Proven Treatment for Hair Loss Now Available in the United Kingdom and Europe
2010-07-02 23:56:54 - Eucapil, a relatively new treatment for male pattern baldness is now available in the UK and the rest of Europe. The product has been clinically proven to help treat hair loss, in a 12 month double blind, placebo controlled University study.
Eucapil is a relatively new product on the market, to treat the age old problem of male pattern baldness. It has been scientifically proven to be effective in double blind controlled clinical studies.
Menspharma, the exclusive UK distributor of Eucapil, whose website can be found at
www.menspharma.com have carried out two user surveys and can now report the following extremely encouraging results:
In the most recent study involving over 150 random users, the following results were reported by current Eucapil users; 62% of respondents fell into the 25 to 40 age range. 73% of respondents reported a complete cessation or slowing down of their hair loss within 1 to 6 months of use and perhaps most significant of all 48% of respondents reported varying levels of regrowth of hair in the vertex (crown) and temple areas.
As the product is topically applied (i.e. directly to the scalp) and is not absorbed by the body, it therefore has the added bonus of none of the unwanted side effects associated with other clinically proven treatments for hair loss currently available, which are absorbed by the body and can cause a variety of unwanted side effects.
In summary, Eucapil is a safe, approved, tried and tested, clinically proven treatment to help fight male pattern baldness
resource: http://www.pr-inside.com/new-clinically-proven-treatment-for-r1982885.htm
How and where is Eucapil® approved?
Eucapil® is approved as a cosmetic hair care agent for topical use in the Czech and Slovak Republics and can therefore be employed as such in all other EU countries.
Is Eucapil® approved in the U.S., Japan or Canada?
Eucapil® is not yet approved for sale in these countries. Depending on the particular regulations , cosmetics can be brought in by travelers or imported for personal use. Please consult your customs agency.
Where is it possible to buy Eucapil®?
Eucapil® can be purchased in selected pharmacies throughout the Czech and Slovak Republics or on-line at www.menspharma.com and www.eucapil-shop.eu which will expedited to other EU and other countries.
Will Eucapil® be effective if applied to the hair?
Eucapil® was designed to be applied directly to the scalp in order to enter the hair follicles thus affecting the hair loss and promoting strengthening of the hair stem. Application of Eucapil® to the hair only would thus not be effective.
How does Eucapil® work?
The mechanism of Eucapil® action is explained in the introduction, Hair Loss .
Will Eucapil® affect hair on other regions of the body?
Eucapil® applied to the scalp skin will promote hair growth only in that region. Effect of Eucapil® formulated as gel has been studied in facial hirsutism (excessive growth of hair in women) where the male hormone promotes hair growth (in contradistinction to the scalp).
Will Eucapil® affect the body systemically?
Daily application of Eucapil® has not affected the normal levels of testosterone in the body. This was demonstrated in a 12-month clinical trial in young males. (see the articles).
What will happen if Eucapil® gets into my eyes?
If Eucapil® runs into the eyes during application, the eyes should be immediately flushed with copious amounts of water. The studies indicate that Eucapil® has a low irritation potential and any ocular irritancy observed in safety studies proved to be completely reversible. As noted in our package insert, we recommend applying Eucapil® with the head tilted back to facilitate its distribution and to prevent exposure to the eyes.
Is the isopropyl alcohol formulation of Eucapil® safe?
Isopropyl alcohol, also known by its common name rubbing alcohol, is used in many cosmetic products, is listed in the Pharmacopeias as a useful topical vehicle which has low hazard potential to human health.
When is the best time to apply Eucapil®?
Although it is recommended that Eucapil® be applied at bedtime, it can be used any time, provided that the scalp is dry.
Will shampoo affect Eucapil®?
No, but for maximum effectiveness Eucapil® should not be washed away soon after the application. It can be applied after shampooing, making certain first that the scalp is completely dry.
What about Eucapil® and sun exposure?
While using Eucapil®, it is not recommended to expose the scalp to strong sun: sunburn, the scalp inflammatory reaction, might be potentiated.
Can Eucapil® be used with other topical hair loss treatments?
We hear that some customers are using Eucapil® concurrently with other hair loss treatments. The effectiveness or safety of Eucapil® in combinations has not yet been studied. Eucapil® may not be applied simultaneously with water based products.
Can women use Eucapil®?
Eucapil® is safe for treatment of hair loss in women. As a precaution it should not be used by women who are pregnant, breast-feeding or planning to become pregnant.
What side effects can I expect from Eucapil®?
To this day, no side effects have been observed from daily topical use of Eucapil® when used as described in the product insert. Patients with a propensity toward seborrheic dermatitis (scalp irritation) may experience a flare-up of their condition attributable to the topical rubbing alcohol component of Eucapil® . These events proved reversible upon cessation of use.
How long must I use Eucapil®?
Eucapil® should be used daily, as long as necessary. We cannot predict individual responsiveness.
Can I increase the dose of Eucapil®?
There is no evidence that increasing the daily dose of Eucapil® would increase its effectiveness.
Can I use Eucapil® twice daily?
The current studies indicate that once a day application of Eucapil® is sufficient.
Can Eucapil® be used with all colors and types of hair?
Yes, but we have occasionally seen that white hair can acquire a light yellowish hue which nevertheless can readily be washed away.
Is Eucapil® still effective if people shampoo their hair daily? Is it absolutely necessary that the user shampoos no more than once or twice a week?
First, one would generally assume that applying anything on the scalp and then washing it right away would probably be counter-productive. Second, Eucapil® was designed to degrade in the water environment. This is a security feature. Eucapil® is resorbed into the skin only, there is no evidence for systemic resorption and any side-effects:. Eucapil® was designed to decompose should it for whatever reason enter the body, (such as accidental ingestion). Therefore, it is important not to apply fluridil to the scalp when wet. Third, shampoos remove the skin and hair fat effectively and thus signal to the sebaceous glands to work harder: a vicious circle is thus established. We hear from Eucapil® users who have reduced their shampooing frequency, washed hair with warm water and some soap only, or used the so-called “dry shampoos” that although it took many weeks before the scalp glands´ activity returned to normal, it eventually did.
What is the topical/local half-life before Eucapil® is absorbed/distributed into the circulation?
Eucapil® is designed not to be resorbed systemically and to act only topically on the scalp skin. Not even traces of fluridil ( measured at the extremely low level of 5 nanograms /ml) or its decomposition products were found in the blood or urine of the subjects who used the product over an extended period of time. Fluridil is also designed to degrade in an aqueous environment, such as if accidentally swallowed. The topical half-life (on the skin) cannot be determined as it depends on the individual humidity and overall condition of the skin.
How soon can we expect the release of Eucapil® in France and other European countries?
The substance fluridil has been registered via France in the EU, and approval of Eucapil® as a cosmetic hair-care agent has been granted in the Czech and Slovak Republics. Eucapil® can therefore be utilized in other EU countries. Several other countries have also approved the product as a cosmetic agent.
Can patients use minoxidil or perhaps other water based topicals in combination with Eucapil®? If people can use minoxidil in combination with fluridil, do they apply minoxidil before, after or simultaneously with Eucapil®?
We have not studied the combination of Eucapil® and minoxidil. If users of Eucapil® decide to explore such combination, it would be reasonable – for the reasons of stability stated above – that minoxidil be applied first and then Eucapil® after, when the scalp is completely dry, surely not at the same time. It should be considered that most formulations of minoxidil contain water which can cause Eucapil® to decompose .
How would you compare the effectiveness of Eucapil® to that of finasteride, dutasteride and minoxidil, respectively?
Eucapil® has not yet been tested in a comparative study with the above media. The data in the Drug Development Research can be compared to the published data for these and other products.
DISCLAIMER
Interpharma Praha, a.s., the manufacturer of fluridil and Eucapil®, and Biophysica, Inc., the holder of patent rights to fluridil, are not responsible for the correctness, completeness, reliability or usefulness of the information provided below. Viewing these questions does not constitute a consultation or the rendering of advice. While there may be information below related to certain medical conditions and their treatment, should a medical condition exist, promptly see your own physician or health care provider. Please consult the labeling of this cosmetic product before using it.
