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Carrying excess fat can raise the temperature around the testicles causing DNA damage to sperm which can lead to fertility problems, a new study shows. The damage could also lead to childhood cancers and fertility problems in the next generation, researchers believe.
However, they insisted that the problems were for the most part reversible and suggested that overweight and obese men wanting to start a family should try to slim down.
Dr Ricardo Bertolla, from the urological research centre in Sao Paulo, Brazil, said: “I do think that this (effect) is reversible.
“I would recommend that these men go on a diet.”
However, he said that men who had been obese before puberty, when a number of major hormone changes linked to fertility take place in the body, could find that the effects of their condition were less easily reversible.
The study adds to growing evidence that obesity can cause DNA damage and also affect the part of the cell which drive sperm as they make their way towards the egg.
Previous studies have shown that overweight men were likely to have fewer sperm than thinner men.
Obesity is thought to affect sperm's performance in several ways, including damaging them through overheating the testicles, by disrupting sex hormones and by releasing greater numbers of “free radicals” thought to damage cells in the body.
The study looked at more than 300 men.
Obese men but not those who were overweight had significantly more damage to their DNA, they found.
Being obese increased the chance of sperm being damaged by more than 60 per cent.
However, Dr Allan Pacey, fertility expert at Sheffield University and secretary of the British Fertility Society, said that the findings should be interpreted cautiously.
He said: "I'm reasonably convinced there's a relationship between sperm quality and obesity.
"Whether that is the same as fertility is another matter - there are plenty of men out there in the community with a high body mass index (BMI) that have fathered children so the link is not absolute."
However, Dr Pacey said it was known that sperm with have a high level of damage "do less well".
The research was presented at the American Society for Reproductive Medicine (ASRM) conference in Atlanta.
Obesity is calculated using the BMI, a ratio measured by dividing a person's weight in kilograms by their height in metres squared.
A BMI of between 20 and 25 is considered, 25 to 30 overweight and above 30 obese.
Point of View:http://www.telegraph.co.uk/health/healthnews/6395038/Obese-men-wanting-children-
should-diet.html
It's a natural concern, for both husband and wife. Couples often want to know, but sometimes don't know how to ask the question. Will things be the same - especially for the man - following a vasectomy?
There’s no effect on masculinity.
Does a vasectomy effect a male sex life? The straightforward answer to this question is a "No." A vasectomy does not reduce a man's sexual drive or his ability to have or enjoy sex. The procedure eliminates only the man's ability to father a child... he can still experience an erection and ejaculation as before.
This is an excellent topic for a candid discussion between husband and wife, and perhaps with the doctor of their choice. Some couples are concerned about a reduced libido or sex drive, but they may be shy about asking the question.
What they may come to discover is, once sterility is complete, they no longer need to worry about accidental pregnancy - and that lovemaking can be more spontaneous, more sensuous and more enjoyable than before.
A vasectomy does not effect the blood vessels or nerves that are part of having an erection or ejaculation. Nothing physiologically changes in that respect.
Two important cautions!
It's important to note that a man will not be sterile immediately following a vasectomy. Talk to your doctor, who will test your semen for sperm before you can have unprotected sex. It may take up to 20 ejaculations or more and several weeks before your reproductive system is free of active sperm.
Another caution is that a vasectomy is not a protection against sexually transmitted disease (STD). If you are at risk of transmitting or acquiring an STD, you and your partner will still need the protection of a condom or other means of protection.
So what’s the difference?
Typically, the only significant difference after a vasectomy is that the sperm normally produced is missing from the semen. The glands that produce semen are not changed by a vasectomy. Sperm is such a tiny portion of the total ejaculation fluid (about 2 percent) that the change can't be noticed. Even the color and consistency of the ejaculate are not changed.
There's no effect on "masculinity," either. The man's body continues to produce hormones as before, and there is no change in any of the male characteristics such as beard or voice. Testosterone continues to be produced and released into the bloodstream. Testicles continue to manufacture sperm, but they don't leave the body. Unused sperm are simply absorbed by the body as normally occurs with or without a vasectomy.
In Summary:
* Talk candidly with your spouse and your doctor.
* A vasectomy will not decrease your sex drive.
* The procedure only eliminates your ability to father a child.
* Sterility is not immediate; your doctor will need to test you and advise.
* Vasectomy is no protection against sexually transmitted disease (STD).
* You can still have an erection and ejaculate.
* The body continues to produce hormones.
* Male characteristics (voice, beard) are not affected.
resource: http://www.vasectomy.com/ArticleDetail.asp?siteid=V&ArticleId=5
Overview
A vasectomy is a safe, easily performed outpatient procedure that provides an effective, permanent form of birth control for men. You should not have a vasectomy unless you and your partner are sure you do not wish to have children in the future.
Many men understandably have fears about a procedure involving their scrotum. The good news is that a vasectomy has absolutely no effect on a man's masculinity, sex drive, ejaculation, ability to have an erection or sexual pleasure.
There is little pain or discomfort during or after the procedure. Some urologists perform a "no scalpel" vasectomy, which uses a small puncture instead of a cut and which may result in less pain and swelling. Both the traditional method and this method are safe and effective. If you have any fears or questions, don't hesitate to talk about them with your urologist.
Why Have A Vasectomy
Vasectomy should be considered a permanent form of sterilization. It is a completely elective operative procedure. It is not an appropriate option for patients who might consider starting a new family or having additional children in the future should their social situations change. The decision to have a vasectomy should be made only after careful consideration regarding the possibility of wanting to have additional children in the future. The decision to have a vasectomy should almost always be made after discussion with the patient's partner. The patient considering a vasectomy should also consider the risks and side effects of an unwanted pregnancy. While there are many other ways to prevent pregnancy, vasectomy is one of the most reliable ways to permanently prevent pregnancy. It requires less expense and is much safer than tubal ligation in women.
History of the Vasectomy Procedure
Vasectomy has been performed in the United States for decades. In 1974 a Chinese surgeon developed the "no scalpel" vasectomy technique. This technique was brought to the United States in 1985. The no scalpel technique is performed by many of our urologists. It seems to provide advantages over conventional vasectomy by reducing the operative time, and decreasing risks of bleeding and discomfort. It is just as effective as a conventional vasectomy. Sperm is produced by both testicles. The sperm leaves the testicle near the upper pole and enters a structure called the epididymis. Inside the epididymis is an 18 ft. long delicate coiled tube that the sperm travel through. The epididymal tube then empties into the vas deferens which is a thick cord-like structure that can be felt within the scrotum. The vas deferens tube travels up through the scrotum into the inguinal canal and dives deep into the pelvis behind the bladder and prostate.
When a man has an orgasm, fluid from the seminal vesicles and prostate mix with the sperm and the combination of this fluid becomes the ejaculate. A vasectomy is performed by removing a section of the vas deferens tube within the scrotum to prevent sperm from being transported from the testicle to the ejaculatory duct area. The tubes from both right and left sides are accessed through the wall of the scrotum and a section is removed. The ends of the vas deferens are then occluded by a choice of several techniques. Some surgeons use sutures or clips, but most physicians use cautery or heat to seal the ends closed.
The Vasectomy Procedure
The vasectomy is performed in the office by the urologist. It is performed under local anesthetic injected through a tiny needle into the skin. For patients who are extremely nervous or anxious, oral sedation is sometimes prescribed at the time of the initial office consultation. The hair may be shaved from the scrotum, and the skin is prepared with an antiseptic. With the conventional vasectomy, one or two scrotal incisions are made with a scalpel and the vas deferens is visualized and a section is cut and removed from both sides. The ends are occluded according to the surgeon's preferred technique. Generally, absorbable sutures are used to close the skin at the conclusion of the procedure. Most urologists have the patient bring a jock strap to hold the dressing in place and provide support for the scrotum for several days. With the no scalpel vasectomy technique, a single puncture is made in the middle of the scrotal skin and the skin is stretched open about 4 mm.
A special clamp is then used to grasp the vas deferens and bring it out above the skin. The rest of the procedure is then performed above the level of the skin. Both sides can be done through a single puncture site. The puncture site is so small that sutures are not routinely used. The puncture site generally heals in one or two days. Some urologists perform open ended vasectomies. The abdominal end of the vas deferens is sealed but the testicular end is left open to prevent pressure induced damage to the epididymis which may decrease the potential long-term complications of chronic epididymal pain.
A vasectomy is a surgical procedure, and therefore has potential side effects. The short-term effects of vasectomy are primarily bleeding within the scrotum, bruising, infection, and discomfort. Infection is very rare. Bruising of the scrotal wall is common but rarely causes pain or discomfort. The primary serious short-term side effect of a vasectomy is the risk of formation of scrotal hematoma. This occurs in about 0.5 - 1 percent of patients undergoing vasectomy in the hands of an experienced urologist. The scrotum is a unique part of the body which will expand under increasing volume allowing bleeding to continue.
It is extremely important, therefore, for the patient to carefully follow the instructions of the urologist in the postoperative period to avoid hematoma formation by resuming activities too soon. Hematomas cause significant scrotal pain, but rarely require additional surgery. The long-term side effects of vasectomy include inability to father children, which is the intended effect of the vasectomy procedure. In addition, chronic epididymal pain can occur in 2 - 4 percent of patients due to pressure-induced swelling of the epididymis.
This can usually be treated with over the counter nonsteroidal anti-inflammatory drugs such as ibuprofen. Sperm granuloma formation is common and is usually asymptomatic if it occurs at the cut end of the vas deferens In the mid-1990's, an article was published which suggested the possibility that having a vasectomy could increase of patient's risk of getting prostate cancer later in life. Multiple studies have since been undertaken which have failed to show a clear link between vasectomy and an increased risk of prostate cancer. The vast majority of scientific evidence finds that vasectomy does not lead to any form of chronic disease, coronary disease, or in the increased risk of cancer.
After Surgery
Patients who are considering a vasectomy should plan on very limited physical activity for two or three days after the procedure is performed. Patients who do primarily office work can usually have the procedure performed on Friday and return to work on Monday. Patients whose jobs involve heavy lifting or strenuous activity, such as firefighters or construction workers, should probably take a few days off of work after a vasectomy. It is very important that the patients avoid any form of strenuous exercise or heavy lifting for five to seven days after the procedure. This is to insure that the patient does not develop delayed bleeding with formation of scrotal hematoma. Most patients can resume full activities, including sexual activity, about seven days after the procedure.
The patient is not sterile immediately after the procedure. It takes approximately 15 ejaculations and several weeks for all of the sperm to be washed out of the ductal system. During this time, it is quite possible to cause a pregnancy.
Alternative forms of birth control must continue to be used during this time. After 15 ejaculations, the patient is asked to bring in a fresh sample of semen for evaluation by the surgeon. This sample should have no sperm in it under microscopic examination. If no sperm are seen, the patient is considered sterile. If any sperm are seen, the patient is warned to continue using an alternative form of birth control and resubmit a semen sample after 10 additional ejaculations. A second semen sample is required within one to six months to insure that recanalization has not occurred during the healing process. Once the second semen sample is found to be free of sperm, the patient can expect to be permanently sterile.
Considerations
The success of vasectomy is not 100 percent. Approximately 1 in 200-400 patients who undergo vasectomy will not have sperm permanently removed from their ejaculate. To put this in to perspective, the failure rate of preventing pregnancy with condoms is approximately 30 percent. Birth control pills and long-term hormone shots are about 97-98 percent effective at preventing pregnancy when used appropriately. Tubal ligation has a failure rate of approximately 1 percent, and when tubal ligation does fail, the mother is at increased risk of a tubal pregnancy. Tubal pregnancies have significant potential complications including death.
Vasectomies appear to be more than 99 percent effective at preventing pregnancy. The only more reliable way to prevent pregnancy is to completely abstain from sexual activity. If you are interested in learning more about vasectomy, please call your physicians. Some ot the urologists require a consultation at the office prior to scheduling a vasectomy. This ensures that all of your questions will be answered, that your examination is normal, and that you are a good candidate for vasectomy.
resource; http://www.myfloridaurology.com/servicesdetails.cfm/ID/17
This post is about what everyone does and what few people like to talk about. In case you didn't know, the color of feces can tell a lot about the health of the body and the foods that are being consumed. Is it human nature to look or do most people just flush it down? If you're one that doesn't notice the color of your poo, you may want to start.
Dr. Steve from Sirius Radio and Men's Health recently discussed what the color of your poo can say about you and your health.
Black- This could indicate bleeding in your upper digestive tract (stomach or above) which results in the blood being processed by the stomach and small intestine that turns it black in color. However, occasional black stool can result from eating spinach, licorice, or blueberries as well as from iron supplements and Pepto Bismol. See a doctor if it's more than occasional.
Red- This can indicate bleeding from the lower digestive tract as the blood hasn't been processed. Some red stools can be caused by red food coloring and beets, but suspected bleeding should be reported to a doctor.
Gray or Yellow- This could indicate problems with your gall bladder as it is bile that actually turns poo brown in color. Have this checked out by a doctor. Aluminum based antacids can also cause light colored stool.
Green- I guess this could be the target color, because greenish brown stool indicates that you're eating plenty of vegetables, however, bright blue food coloring can also produce green poo as it mixes with the yellow bile to produce the color green.
Sorry for the "bathroom talk" post, but checking your poo is a good thing to do, especially when it comes to keeping an eye on what's going on inside and into your body.
One of the most useful resources is the Bristol Stool Scale - developed by the University of Bristol.
Types 1 and 2 indicate constipation, with 3 and 4 being the "ideal stools" especially the latter, as they are the easiest to defecate, and 5-7 tending towards diarrhea.
resource: http://www.diet-blog.com/10/poll_what_does_your_poo_say_about_you.php
Do you take time to look at the color of your stool?
Seth Rogen has claimed he achieved his superhero physique for new movie The Green Hornet thanks to "poop-related weight loss".
The 28-year-old actor and comedian - known for his roles in Knocked Up and Pineapple Express - has toned up his figure to don a costume in the new action adventure.
Seth joked at Comic-Con at the weekend that he had lost: "400lbs all through s**t! That's what most people don't know, all poop-related weight loss."
Asked how he planned to regain the weight he quipped: "Well, since I lost it through poop I think you know where I'm going, the answer is I'm going to eat my own s**t!"
In The Green Hornet, Seth plays a superhero who wields a blowtorch and has a Chrysler equipped with hood-mounted machine guns.
The film doesn't open until next year, but the Superbad star showed a brief 3D clip to about 6,000 fans at Comic-Con, San Diego's annual pop culture convention.
Seth revealed: "To start with someone like me and to see the journey it would take that type of person to become a superhero is an interesting way to approach this movie, as opposed to starting with someone who's a thunder god or something like that! We thought to start as far away from being a superhero as possible would be interesting."
Rogen was joined by director Michel Gondry, co-writer Evan Goldberg, producer Neal Moritz and co-star Christoph Waltz to discuss the film. The Green Hornet opens in January.
resource; http://www.belfasttelegraph.co.uk/breaking-news/entertainment/seth-rogens-weight-loss-secret-14889170.html#
resource: The Orange County Register Loneliness, depression and social isolation cause men who've been divorced, widowed or never married to die at a much higher rate than married men, Harvard Men's Health Watch reports.
"Happily married men might add health to the things they thank their wives for," says the article in the July issue. The mag culled various studies to arrive at these conclusions:
* A survey of 127,545 American adults found that married men live longer than men without spouses, and that men who marry after age 25 get "more protection" than those who marry at a younger age.
* A report from the Framingham Offspring Study, in which 3,682 adults were evaluated over 10 years, shows that married men had a 46 percent lower death rate than unmarried men.
* That study indicated no difference between men who were in happy marriage vs. those who were miserable. But other studies showed a link between the stress of marital unhappiness to hypertension, a key risk factor for cardiac disease.
* Unmarried cancer patients are less likely to receive treatment for cancer, and more likely to have an advanced disease at the time of diagnosis. Among men with prostate cancer, 69 percent who were married survived a median of 69 months, compared with 49 months for those who never married and 38 months for widowers.
* Although men tend to die before their wives, they take losing a spouse much harder. In a study of 12,522 married couples over a 14- to 23-year period, 1,453 men and 3,294 women lost their spouses. Healthy men were 2.1 times more likely to die during the study period than healthy men who were not bereaved.
* A Harvard study says socially isolated men are 82 percent more likely to die from heart disease than men who have strong interpersonal relationships.
Married men also tend to take care of themselves better and do a better job of seeking out preventive medical care, which points to the benefits of having someone who cares about us prodding us to reduce bad habits and get to the doctor regularly. "One reason that widowers fare so poorly is that nutrition and other health habits deteriorate when men are on their own," the article states.
Plastic Surgery Portal Many men (and women) strive for those ever-desirable six-pack abs these days. Yet, tireless stomach crunches and sit-ups often don’t get the job done, no matter how disciplined you are about your regimen. The truth is, it can be very difficult to eliminate the layer of fat around the mid section, particularly if you are not genetically blessed in the abdominal region to begin with. However, there is a secret weapon many men have turned to for defined abs and that legendary six pack look-- abdominal implants.
Ab Implants vs Abdominal Etching
Also known as six-pack implants, abdominal implants are an alternative to another popular procedure known as abdominal etching. Etching is a form of liposuction that gives you a flat, tight stomach with greater muscle definition. The surgeon removes excess fat, and then creates grooves in remaining fat layers to simulate the appearance of toned abs. Abdominal implants, however, are actual implants designed to mimic the look of the six-pack, and they can provide an even more defined appearance than abdominal etching.
How Abdominal Implants Work
The six-pack implant procedure involves an incision at the belly button, through which the surgeon can place six to eight individual implants. The implants lie over your actual musculature, and are designed to conform to the underlying muscle, and be supple and flexible enough to move with your bodily activity, while also feeling natural to the touch. In many cases, the implant surgery is coupled with a tummy tuck procedure to provide better access to your abdominal muscles before the insertion of the implants.
Abdominal Implant Risks
As with any surgery, some risks are involved. Side effects from anesthesia may occur, in addition to risks of infection. Bruising, swelling, and temporary aches will occur, but should subside within a week after surgery. To learn more about the potential risks of abdominal augmentation procedures, including abdominal etching and abdominal implants, you should speak to your surgeon.
Non-Surgical Alternatives:
Sculpt up with lower abdomen exercise and get rid of those love handles with exercise. Here is how!
Stomach Muscle Exercise
A good abdominal workout program requires high intensity muscular overload and an increase in intensity progressively. Stomach exercise must be performed carefully so that the lower back is supported properly.
Stomach exercise can help build the entire abdomen region because the upper and lower abdominals are not separated and are connected. Of course, there are some stomach exercises that can help build and strengthen specifically the lower and upper abdominal muscles.
Abdominal exercises can help you also gain strong stomach muscles and back muscles. This can reduce the likelihood of back pains and provide protection against injury by efficient response to stress.
Lets have a deeper look into the muscles in the abdominal area. The Rectus abdominals is the muscle that stretches down the stomach from your ribs to the hips. The external and internal oblique run down the sides of the waist and their job is to rotate the torso and assist the abdominals during curling and twisting movements.
Stomach exercises are needed to tone or harden the muscles in that area. Not only that, the layer of body fat that is covering the abs must be burn off and this could be only done with proper eating plan. Try to increase your protein intake and limit your carbohydrates, eating a low carbohydrate diet is said to be one way of tackling flabby abs along with a sensible abs exercise routine, strength training and cardio exercise.
Stomach exercise
Stomach exercise must be followed religiously and is all about frequency rather than intensity. No exercise must be continued if it leads to pain or extreme discomfort. The best stomach exercise program can also help you achieve a flat and tight stomach. Many an abs exercise can be performed on the floor. Like any other muscles, the abdominal muscles will react to resistance training like bicep curls and crunches.
A simple pelvic tilt performed while sitting in a chair can strengthen your abdominal muscles and help support the back.
Best Stomach Exercises
Crunch
Lay on your back and knees bent, lift your shoulders off the floor. The emphasis is on moving the ribs towards the hips.
Reverse Curl
Lay on your back, bend your knees towards the chest. Keep the hips on the floor. Contract your abdominal muscles at the same time. Your lower abdominal exercise program must include reverse curls.
Leg raise
Single leg raise involves raising one leg from the floor. The double leg raise involves raising both legs from the floor at the same time and this works as an abdominal muscle exercise. Lying leg raises are ideal lower abdominal exercise
Abs exercise with the ball
The stability ball is an effective training device for the abs and lower back. Due to the curve of the exercise ball, the lower abdominal muscles get trained better on account of the greater range of motion.
Bicycle
It was ranked the best abdominal exercise by the American Council on Exercise. When performed with the abs muscles pulled, this exercise does great things for you.
Plank
For this exercise program, you need to position yourself for a pushup and hold the pose. Ensure that your body is in one long, straight line from head to toes.
Captains chair
This abs exercise involves standing on a gym chair and gripping the handholds. Press your back against the head pad and slowly lift your knees towards your chest. The back must remain straight.
Postnatal stomach exercise
A lot of women just cannot wait to get back in shape after childbirth. But before they can participate in any postnatal weight loss exercise program, they have to consult their doctor first.
Pelvic tilts and simple abs contractions are an ideal way to start on a postnatal lower abdomen exercise program. Combined with Kegels exercise, you can get your pelvic floor muscles back in shape. Isometric contractions can even be practiced with the baby on your stomach. Stick to a steady lower abs exercise program and watch the flabby skin harden.
Stomach exercise to flatten stomach
Getting a lean defined six-pack abs is a dream for most of us. Millions of dollars are spent yearly in the process of achieving a flat stomach and trim waistline. There are many gadgets that are sold to those seeking an exercise program getting the stomach fat down.
The first step towards a lean waist and flat stomach is to remove the fat that sits on the abs. A combination of cardiovascular exercise program coupled with a low fat diet aimed at preventing fat can do wonders. Stomach exercise program would include the following:
Forward flexion exercises such as sit-ups and crunches.
Rotational exercises such as trunk rotations and standing twists
Stomach Exercise for love handle
Love handles are a misnomer, as all women would love to shun them. Love handles are the ugly fat belts around the waist. This lump of flesh starts at the side of the bra-line and extends all the way down the back. Aerobic exercise aimed at this region can help you shed those love handles. Exercise for love handles involve exercising the oblique muscles to tighten up the sides of the waist. Abs crunches could also do the same.
Here is an easy stomach exercise for the oblique that you can do at home.
Sit upright with a stick across the back of your shoulders. Twist from side to side. Side bends also work wonders on love handles. Keep at it and watch these muscles firm into place.
resource: http://www.yourhealthkick.com/?p=856
Flat bellies aren't only for women
Google Images
There is a new diet book created just for men. The editors at Prevention Magazine have done it again! The original Flat Belly diet targeted women and was met a huge success. They discovered that men wanted a diet just for them.
It's called The Flat Belly Diet for Men.
Studies shows that as many as 70% of men in this country are overweight. Men also have a much greater chance of carrying excess fat in the most dangerous area: the belly. With women, fat has a tendency to carry fat in their hips and thighs.
The diet limits men to 2000 calories per day. It also focuses on 5 core foods: avocado, oil, olives, nuts and dark chocolate. These foods are rich in MUFAS (monounsaturated fatty acids). A Spanish study showed that these fats actually stop weight gain around the belly.
The Flat Belly Diet for Men
incorporates these foods in each meal. The recipes are male focused; giving consideration to foods many men consider essential: meat, grilled foods, and beer. The diet even has a special water that is supposed to boost the metabolism. It is made with ginger, spearmint, lemon, cucumber, and cayenne pepper. Men who participated in a 32 week study for the diet lost an average of 13lbs and 9inches.
Eli Lilly and Co., which helped turn impotence drug Cialis into a household name, is moving aggressively to put other products in men's medicine cabinets.It's a move that could yet again broaden Lilly's reach beyond its traditional role of developing drugs for diabetes and mental illness.
Prompted by an aging male population, the Indianapolis drug maker is gearing up to develop and sell new treatments for enlarged prostate, low testosterone and other ailments that affect millions of men.
On Thursday, Lilly said it had advanced an experimental drug for treating enlarged prostate from early-stage to middle-stage clinical trials, a sign that the drug has worked safely in healthy volunteers. The company is enrolling men with enlarged prostates in a 24-week test to see how well the drug, known as LY500307, can treat the ailment.
That follows Lilly's announcement in March that it signed a worldwide license agreement with an Australian biotech firm, Acrux, to sell an experimental gel for treatment of testosterone deficiency, which affects up to 39 percent of men older than 45.
The gel, called Axiron, is applied over a small area of the body with an underarm applicator. The product is now under federal review, and Lilly hopes to get approval by next year.
If these moves work out as planned, Lilly could become a more significant player in men's health. It's a fragmented but growing market worth billions of dollars a year in sales.
"There are a lot of companies with lots of different products that touch men's health, but no one really is a clear leader," said Linda Bannister, a drug analyst at Edward Jones & Co. in St. Louis. "There's an opportunity for Lilly here."
Developing new drugs takes years, and some analysts doubt that Lilly will be able to make a huge impact immediately. But if successful, Lilly could reap untold billions in new sales, which could help the company as it struggles to cope with a steep falloff in sales from other leading products, which are about to lose their patent exclusivity and face low-cost generic rivals.
Lilly has a good foothold in this area already. Cialis, a popular treatment for erectile dysfunction, is still selling briskly after seven years on the market. On Thursday, Lilly said second-quarter sales of Cialis climbed 15 percent to $418.7 million, putting it on pace to trounce last year's sales of $1.6 billion.In addition to owning the Cialis brand, Lilly has amassed something else just as valuable: contacts with thousands of urologists around the world who have prescribed Cialis millions of times.
"If you go to most urologists, they know Lilly pretty well," said John Bamforth, a Lilly executive who oversees men's health. "So it seemed logical for us to see if there were any other opportunities in this area where we could use contacts and teams we already have."
Already, Lilly is using the compound behind Cialis for other purposes. A few years ago, Lilly received approval to market the drug under another name, Adcirca, to treat high blood pressure. And it is studying the drug as another treatment for enlarged prostates. That test is in late-stage clinical trials. How Lilly got to this position is a mixture of chance, good timing and a bit of catch-up. In 1998, rival Pfizer launched a revolutionary drug, Viagra, the first oral treatment for erectile dysfunction. It quickly became a success, ringing up $1 billion in annual sales within just a few years.
Other drug makers, including Lilly, recognized the opportunity and began looking for ways to capitalize on it.
Lilly struck a joint venture in 1998 with Icos Corp., a Seattle biotech that was developing its own treatment for erectile dysfunction. The drug, Cialis, hit the U.S. market in 2003. The company hit the national stage with a memorable TV commercial for Cialis during the 2004 Super Bowl. The ad showed middle-aged couples relaxing in side-by-side bathtubs at sunset.
The product quickly became a top seller, eventually overtaking Viagra in more than a dozen countries, including France, where it became known as "le weekend," because a single dose can last as long as 36 hours. It remains the only ED drug that works for that long, rather than wearing off in just a few hours, so there's less pressure for men to watch the clock.
In 2007, Lilly bought out its partner, Icos, for $2.3 billion, taking full control of Cialis and ending a partnership that lasted nearly a decade."Back in 1998, when we originally did that deal, we saw it as a bit of an opportunistic play," Bamforth said. "I don't think we planned it necessarily as a path beyond the one asset (in men's health)."He added: "But now it's something we can build on, and leverage our experience and expertise in this growing area."
Meanwhile, Lilly faces new challenges to keep sales robust.Several other companies are developing new ED drugs. And Viagra will lose its patent exclusivity in 2012, allowing competitors to introduce generic versions that could pull down prices for the entire category.
Some analysts say Lilly's effort to broaden its portfolio in men's health is worth a try. Other drug companies have only a handful of products in this area, including GlaxoSmithKline, which sells drugs for erectile dysfunction, overactive bladder and enlarged prostate.
"It's an area where Lilly won't have much competition," said Les Funtleyder, a drug analyst at Miller Tabak & Co. "If they're successful at this, they'll do pretty well."
resource: http://www.indystar.com/article/20100723/BUSINESS/7230356/1003/BUSINESS/At-
Lilly-the-success-of-Cialis-is-fueling-a-push-for-new-male-health-drugs July 23, 2010
When GQ and Allure recently joined forces for their 2010 Grooming and Beauty Study, they discovered that 93% of men find the term metrosexual offensive. Speaking of the obvious! The term grew to popularity in the late 90s and early twenty-first century when, both, men starting embracing it's meaning and women started giving it a name. Snap back to the reality of the present, however, and there seems to be a new movement in order; a movement some call retrosexual. If the earlier hailed a trend over the past decade of an overly-manicured and somewhat emasculated man, the latter is a renunciation of that trend. While retrosexuals are heralding the styles and values of traditional masculinity—they are doing so with an entirely different perspective, post-metrosexual male, with a heightened understanding and likening of brands, aesthetics and lifestyle.
Think Justin Timberlake's love for fedoras, David Beckham's penchant for flannels and Johnny Depp's old-era eyeglasses; these are subtle examples of the retrosexual. But they come in more extremities: the flannel-clad urbanite with rustic hair, nouveau gentleman on a motorbike or tattooed soldier in a J. Crew chambray shirt.
The rising trend can easily be seen in the growing popularity of brands that exude Americana and heritage—brands like J. Crew, Woolrich, Gilded Age, Red Wing boots and even vintage Ray Bans. Retailers are also feeding into the craze, providing old-school environments based on traditional values of masculinity. Tom Ford flagships connote the look of bachelor pads and the J. Crew Liquor Store and John Varvartos flagships shine light on a Depression-era general store. Betrand Pellegrin, author of Branding the Man, argues that men's retailers in general adopt this strategy. "In order for the male customer to understand the merchandise, it needs to be framed in a way that makes sense and can be instantly read as 'masculine'."
What has sparked such a backward glance at the masculine normality of yesteryear? Cultural observers say blurring gender roles and economic insecurity. Unemployment has impacted men more severely than women, and gender parity has resulted in men and women playing equal roles at work and home. "There is less difference between the sexes than ever, and one way guys deal with that is by adopting the styles and attitudes of previous generations," explained Ian Pierpoint. In fact, Michael Kimmel, a sociologist at the State University of New York, recalls a study that showed that men grew their sideburns and beards during times when women made visible strides toward equality. "If the sexes are equal, men will gravitate to things that differentiate them."
Without doubt, this has resulted in fashions that are a juxtaposition of polished and rugged, well-made and worn-in. Men want to look as if they've made an effort, but with products that have stood the test of time. That seems to have been the aesthetic for the Fall 2010 collections of Billy Reid, Gilded Age, Levi's and tons of other brands; not to mention the entire being of J. Crew menswear.
If anything, the metrosexual trend has resulted in men feeling that having good clothes and brands is an important part of life. Which it is! The retrosexual craze is allowing them to do that while grabbing hold of their balls and screaming, "I am man, hear me roar!" And by all means, I like the latter much better.
resource: DistrictCut.com
Emory Healthcare is the clinical arm of the Robert W. Woodruff Health Sciences Center of Emory University, which focuses on patient care, education of health professionals, research addressing health and illness, and health policies for prevention and treatment of disease. The backbone of this system is the Emory University School of Medicine, which has been at the forefront of medical knowledge and research, pioneering many advances and procedures that have changed the face of medical history.
Our board-certified surgeons provide abdominal wall reconstruction; breast reconstruction (especially immediately after mastectomy); breast lifts, augmentation, and reduction; correction of craniofacial and congenital abnormalities; body contouring; free tissue transfer; head and neck reconstruction; oculoplastic surgery; microsurgery; pediatric plastic surgery; reconstruction following surgery for skin cancer; scar revisions; surgery of the hand and upper extremities; and thoracic reconstruction.
In coordination with the referring physician, the first visit includes the development of a treatment plan based on your individual medical needs. The initial visit will include an evaluation based on current symptoms or conditions, the compilation of a thorough medical history, and a physical examination.
To ensure the most effective treatment plan, please bring all pertinent medical records and allow extra time for paperwork and photography. Please do not assume your primary care doctor has already sent your records to our office unless we have verified their receipt.
Our primary clinical location is Suite 4300 on the 8th floor of the Medical Office Tower at Emory University Hospital Midtown, 550 Peachtree Street, Atlanta, GA 30308.
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The Emory Facial Center is to help you with a team approach that combines exceptional care with the latest technology and techniques, ensuring that you get the best possible results. Led by Seth A. Yellin, M.D., board-certified facial plastic surgeon and Chief of Facial Plastic Surgery, the Emory Facial Center provides comprehensive cosmetic facial procedures, both surgical and non-surgical, as well as hair restoration services.
Men with a long ring finger could be three times more likely to develop prostate cancer, research shows.
Doctors found that the risk increases if the ring finger on the right hand is significantly longer than the index finger next to the thumb. But men whose ring fingers are only slightly longer, or are about the same length, are much less likely to get the disease.
The findings open up the possibility of screening men with longer fingers at an early age for signs of cancer.
In the study, blood tests showed that men with longer ring fingers on their right hand had higher levels of prostate specific antigen (PSA).
This chemical is sometimes found in high levels in blood when cancer is present. The right hand was studied because the difference between the length of its ring finger and index finger is often greater than on the left, as it is more sensitive to hormonal changes in the womb. The results are the latest in a long line of studies linking finger length to men's health, most of which highlight the benefits of a long ring finger.
These include reduced risk of heart disease, a better chance of exam success and increased fertility.
Last year a team of experts from the Medical Research Council's Epidemiology Resource Unit at Southampton University even found that young men with longer ring fingers made better sprinters.
The key to these findings is thought to be the level of exposure to the hormone testosterone in the womb.
Higher levels also make it more likely that a boy will have a slightly longer ring finger on their right hand. Testosterone is also known to stimulate prostate tumour development.
In the latest study, doctors at Gachon University Gil Hospital, in Incheon, South Korea, studied 366 men over the age of 40 who went to a hospital clinic complaining of problems urinating, a symptom which could be a warning sign of cancer.
They had their fingers measured from the crease where the finger joins the hand to the tip.
Blood tests showed that men with much longer ring fingers had almost double the levels of PSA found in the blood of those with shorter fingers.
Three times as many of these men went on to be diagnosed with prostate cancer. Researchers writing in the British Journal of Urology online said the 'digit ratio' - the difference in length between ring and index finger - could be used to predict which men could get cancer.
'Digit ratio is a predictor of high PSA levels and the presence of prostate cancer,' they said.
'We believe our results present sufficient evidence that a relationship exists between the two.'
Nearly 32,000 cases of prostate cancer are diagnosed a year in the UK and 10,000 men die from it - more than one an hour.
But Ed Yong, Cancer Research UK's head of health information, said: 'Finger length ratios have been linked to all sorts of things before with little evidence that measuring these ratios will ever actually be useful.
'For example, this very small study finds an association between finger length ratio and prostate cancer risk, but tells us nothing about whether the ratio can be used to reliably predict that risk.'
If you are considering a facelift but hesitate due to the recovery period from the surgery you may be a candidate for a microcurrent facelift. What is a microcurrent facelift? It is a non-surgical, non-invasive plastic surgery that is safe and efficiently improve the appearance of the skin. Also known as a Bio-ultimate facelift, the microcurrent facelift uses technologies developed in the medical and physiotherapy fields to activate the skin’s natural chemical response for health and vitality. It is safer than the traditional facelift with fewer side effects and at a fraction of the cost.
A microcurrent facelift benefits the patients by helping them attain a healthier, younger looking appearance which improves muscle tone in the face, neck, jowls, eyebrows while reducing fine lines and wrinkles, improve facial circulation, skin exfoliation, lymphatic drainage, sun damage, age spots, acne scars and more. It uses gentle electrical stimulation to trigger the skin’s cellular level. Clinical studies have shown that after twenty days of treatment collagen production increases by 14%, elastin by 48% and blood circulation by 38% all the while producing amino acids and ATP that accelerate cell repair and promote cell production. The microcurrent treatment works by applying gentle electric stimulation to the surface of the skin using fine dual prongs applied to various regions of the face.
Despite what you might think – it’s not at all painful. You may experience slight tingling but most people find it relaxing and many actually fall asleep. This procedure isn’t new as it was originally developed to treat those with facial palsy and in sports medicine. They discovered the visual improvements to the tone and texture of the skin and it became apparent that it could also be used for the cosmetic industry.
The best candidate for a microcurrent facelift is anyone that wants a younger, youthful appearance. Younger clients can seek a microcurrent facelift to prevent some of the aesthetic effects of aging and older patients can find their skin rejuvenated. If you are interested in having a microcurrent facelift, you should speak to your doctor or dermatologist so that he can recommend a qualified cosmetic surgery. An initial consultation is recommended to review the benefits and what is expected before, during and after the treatment. This information will help you develop realistic expectations about the results from the procedure.
The microcurrent facelift procedure itself takes approximately one hour to complete and is virtually painless. A microcurrent facelift specialist will use a two pronged cotton tipped instrument to gently deliver electrical stimulation to the muscles and tissues of the face and/or neck. The microcurrent facelift procedure requires no anesthesia, no recovery time, no down time from work, and has no irritating side effects. Most people need a course of around 10 microcurrent sessions to see the full benefits – although many claim to see immediate results from the first treatment. The exact number you need will depend on your skin tissue and muscle tone – not necessarily on your age.
After the initial course of microcurrent treatments, you only need to return for a booster treatment on average around every 4-6 weeks. If you don’t follow the maintenance plan – you’ll lose the improvements in tone, radiance and lift.
You can expect to pay around $100 for one session which will last an hour so your initial course of 10 sessions will come in at $1000 or so depending on the cosmetic surgery center location.
Obviously this isn’t a small amount of money but compared with facial cosmetic surgery a course of microcurrent treatments is great value. And you won’t need to spend the $1000 all over again five years down the line. Provided you stick with a maintenance schedule your results will last – unlike facial cosmetic surgery or other types of non surgical face lift which need to be repeated as improvements are lost over time.
And if you don’t want to spend so much – consider a home hand held microcurrent device. The NuFace Microcurrent Skin Toning Device is available on Amazon.com as well as other online websites.
Amazon Product Description
NuFace Microcurrent Skin Toning Device is the first FDA approved anti aging skin care product for facial toning. Use the NuFace microcurrent facial machine daily to enhance the natural beauty of your face and skin without plastic surgery! Unlike other anti aging and facial toning products that consist of a large microcurrent facial machine with wires and probes, the NuFace Microcurrent Skin Toning Device consists of a hand held, enclosed unit without any wires.
The NuFace Microcurrent System uses safe, painless, low-level, waveform-shaped currents (electrical impulses) to "reprogram" the muscles to almost original muscle shape. The electrical impulses rehabilitate the muscles and improve circulation, texture, tone, and fine lines. Use the NuFace Microcurrent Skin Toning Device for facial toning and anti aging regularly to continue to provide muscle strength and restore freshness to appearance.
Is NuFace® cleared by the FDA?
Yes, the spa-quality NuFace® device we offer is cleared by the FDA as a Class II Medical Device that is safe and effective for at-home personal use. It safely and effectively improves the appearance of the face and body through the use of microcurrent technology. The muscles and skin tissues are lifted and toned utilizing the NuFace’s non-invasive and gentle electrical stimulation. “The NuFace® device is bringing anti-aging to the next level. Where Botox has made the anti-aging market turn on its heels, the micro-current NuFace® device is a new and innovative skin health product,” says Dr. Peter Pugliese.
How Does the NuFace® device work? This non-invasive approach to facial rejuvenation can be used just 5 minutes a day to improve improve muscle tone in the face and neck. Simply glide the NuFace® device along the contour of the face (as shown in the video you will receive with your unit) while a gentle alternating current is emitted through dual spherical probes. The intensity level is adjustable.
On the first day, God created woman, on the second day came Man and some time during the afternoon of the sixth, allowing His mind to wander, He created male nipples. Well, not quite, but as Brian Charlesworth, professor of evolutionary biology at Edinburgh University explains, male nips are a bit of a Darwanian afterthought.
Breasts and nipples have evolved in mammals to allow mothers to provide milk to their young. Male mammals rarely care for their offspring and so have no need for them. The evolution of these structures involved developmental changes that are hard to restrict to just females, because the genes responsible are present in both sexes.
Originally, breasts and nipples may well have been present in both male and female mammals—100 or so million years ago. There may have been natural selection to reduce their size in males since there would be possible harmful side effects of their presence (increased susceptibility to cancer).
They simply have not been completely eliminated. Think of your nipples like your appendix. That’s still no reason to remove them, mind you!
I found blood in my semen. Is it serious?
- Gagan Sethi, New Delhi
Calm down, it’s a routine plumbing problem. “One in 100 men experience this condition, known as haematospermia and it’s usually nothing to worry about,” says Dr Kapil Juneja, a consultant urologist, Moolchand Medcity, New Delhi. “The cause is likely to be harmless infl ammation of your prostate or seminal vesicles, however, you should get it examined to rule out infection and bleeding disorders.” Haematospermia usually goes away on its own after about a month, although 25 per cent of men will probably experience it again. (Urologists aren’t sure why.)
If it persists for three months, or if you’re 40 or older, see your doctor for a PSA test. It could be something more serious; prostate cancer accounts for about 2 per cent of haematospermia cases. Follow doctor’s orders—they can be fun. “Ejaculating at least once a week improves your urologic health, decreasing the chances of haematospermia,” says Dr Juneja.
Why do I talk in my sleep?
- Shantanu Behel, Bangalore
Think of it as a kind of a brain fart. “Your sleeping brain is actually very active, but it doesn’t have a censor, so random words can come out of your mouth,” explains sleep disorder specialist Dr Manvir Bhatia, Sir Gangaram Hospital, New Delhi. “Often the content is just refl ective of your brain’s sleep activity and it can be words, sentences or gibberish.”
If your unconscious utterings are bothering your bedmate, cut back on your evening alcohol and try to find ways to lower your stress level. Both booze and chronic tension can disturb your sleep patterns and that in turn may amplify your verbal outbursts.
Just one word of caution: “If your pillow talk becomes frequent, prolonged or increases in volume or profanity, see your doctor ASAP,” says Dr Bhatia. Any one of these changes could signal that you’re suffering from a sleep condition, such as sleep apnoea, nocturnal seizures or REM sleep behaviour disorder (the acting out of dreams with yelling, punching and jumping out of bed).
How can I get more defi nition in my biceps? I want those veins to pop.
- Gaurav Gill, Hyderabad
Don’t think about building the biceps. Weight lifting won’t make your veins any bigger. To get a bulge in that cephalic vein (that’s the one that runs over your biceps), you’re battling a tag team of genetics and flab. Since you can’t do anything about your genes, aim for less than 10 per cent body fat, suggests Micheal Mejia, CSCS, a Men’s Health exercise advisor. Focus on exercises that work large muscle groups and do high-repetition sets with little rest in between. Try this variation on the clean and press.
Stand with your feet shoulder-width apart and hold a pair of dumbbells with your palms facing your hips
1. Bend your knees and drop into a squat position
2. Letting the dumbbells come to rest on the floor. Make sure your back is straight and your knees don’t extend beyond your toes. In one move, kick your legs back, letting your weight rest on the dumbbells and your toes, as if in a pushup position
3. Reverse the move and stand, pressing the dumbbells overhead
4. Do two or three sets of six to 10 repetitions, resting for 60 to 90 seconds in between.
US News and World Report: Having a few more cups of coffee and running that extra mile each day can reduce a man's risk of dying of prostate cancer, two studies indicate.
The case for coffee and physical activity as prostate cancer preventatives is far from proven, according to the research reported Tuesday at an American Association for Cancer Research meeting in Houston. But data from the Health Professionals Follow-Up Study show a clear association with both daily activities.
"I wouldn't recommend that people change their coffee-drinking habits based on this study," said Kathryn M. Wilson, a research fellow in epidemiology at the Harvard School of Public Health, and lead author of one report. "But if you like coffee, there is no compelling reason to cut back at this point."
Her data on the nearly 50,000 men in the study showed how common a diagnosis of prostate cancer has become since widespread screening began. In the 20 years from 1986 to 2006, 4,975 cases of prostate cancer were diagnosed, affecting just about 10 percent of the men in the study.
But only 846 of those cancers were life-threatening, because they had spread beyond the prostate gland or were growing aggressively, Wilson said. And while the study found just a weak relationship between consumption of six or more cups of coffee a day and a reduced risk of all forms of prostate cancer (down about 19 percent), the reduction for the aggressive form was much more marked -- 41 percent.
And there was a clear relationship between the amount of coffee consumed and prostate cancer risk, Wilson said: "The more coffee you drank, the more effect we saw."
The caffeine in coffee doesn't seem to be the link, since the same reduction was seen for consumption of decaffeinated coffee, she said. Instead, "it has something to do with insulin and glucose metabolism," Wilson said. "A number of studies have found that coffee is associated with a reduced risk of diabetes."
This study is just a starting point for establishing a relationship between coffee and prostate cancer, Wilson stressed. "At this point, we would just like to confirm whether it exists in different populations," she said. "We hope that this study drives more research so that we really know what is going on."
The other study, by Stacey A. Kenfield, a research associate at the Harvard School of Public Health, looked at the levels of physical activity among 2,686 men in the study who were diagnosed with prostate cancer. It found, as many other studies have, that exercise is good for overall health, with a 35 percent lower death rate for men who reported three or more hours a week of vigorous physical activity, such as jogging, biking, swimming or playing tennis.
And the death rate from prostate cancer for men who exercised vigorously was 12 percent lower than for those who didn't -- a figure that did not quite reach the level of statistical significance because the numbers were small, Kenfield explained.
Nevertheless, "this is the first study to show an effect of physical activity not only on overall survival, but on prostate cancer survival," she said.
It's already well known how physical activity reduces overall mortality, Kenfield said. "It affects immune function and reduces inflammation, among the major processes involved. But it's not clear yet how it is related to prostate cancer and survival."
I love a well-dressed man; who doesn't? It's so refreshing to see a stylish man during the summer amongst the sea of baggy cargo shorts and sweaty wifebeaters, and so in an effort to eradicate this male fashion travesty, I've put together a handy guide for men to help you fashionistos look top-notch in summer 2010. Below are my shopping picks as well as six suggestions for how to wear them.
1) Start simple with a clean, simple, and lightweight white shirt; you can build many looks from this summer staple. As I said previously, orange is the hottest spring/summer trend for men, and so I highly recommend incorporating it into your look. Pair the white shirt with some flat-front orange shorts.
2) To dress it up, add a navy blazer with orange cuffs as an eyecatching accent. From there, warm-weather basics like Ray Bans and boat shoes (try navy for a nautical look) will complete the look.
3) If you want to wear the orange shorts but go more casual, try an interesting graphic tee and go sans-blazer. Still pair with boatshoes; don't give in to wearing mandals!
4) For a sophisticated white-out look, pair the white shirt with some white-wash jeans and add a seersucker tie to bring some attitude. Again, the navy Sperry's will look great, and donning shades is a must.
5) To continue with the orange theme, buy a basic orange crew-neck shirt. You can wear this with the white-wash jeans or khaki shorts, and adding a navy blazer and some nautical anchor cufflinks will allow you to dress up this look.
6) The last look I recommend is wearing the basic orange crew-neck and wearing the white shirt open over it. Pair with the white jeans or khaki shorts, shades, and boat shoes to have a classy but casual look.
As you can see, with the right basics the possibilities for great men's summer style are endless. Find what look suits your style best and prove that you can be a fashionisto even in hot, sticky weather.
or its generic version Dapoxetine which is the first
pill form medication designed purposely to treat
premature ejaculation (PE) in men. Premature ejaculation, being defined as ejaculating quicker than their partner or themselves would desire. Technically Dapoxetine or Priligy® is what is known as a SSRI
(selective serotonin reuptake inhibitor). SSRI's are typically prescribed for patients that experience depression and as such are used as antidepressants. However some SSRI's have shown the ability to reduce ejaculation time in some men but no other SSRI in studies has worked as well as
Dapoxetine for this issue.
Apparently it is also safer and eliminated from the body quicker than typical SSRI's as its terminal half life is approximately 20 hours with its initial half life around 1.4 hours. This is partially why it was rejected as a depression treatment. Because of its short duration a patient would need to be taking this medication several times per day for a proper effect, which is fairly unrealistic and as such Dapoxetine has not been actually approved as an antidepressant.
Simply put this drug instructs the brain to delay ejaculation. It also does not change the sensitivity of the male sexual organs. Some products have been created that numb this area but get very mixed and often negative reviews. Priligy®/Dapoxetine is not considered a permanent cure for premature ejaculation but when it is taken approximately three hours before sexual activity it can work very well. Studies show it can work in up to seventy percent of men facing this problem and has shown to postpone ejaculation by upwards of three times.
In a study, when men took 30mg of Priligy®/Dapoxetine they increased to ejaculation from 1 minute 45 seconds to just over 2 minutes 45 seconds. The men, who received 60mg of the drug, lasted just over 3 minutes thirty seconds. In a further study with around 2600 patients the researchers found that this medication increased the time a man could last upwards between 3 to 5 times their normal. Results would vary for each individual but averages definitely show a very large improvement much to the delight of both its users and manufacturers. They also determined that this may safely be taken by men between the ages of 18 to 64 provided that they are healthy enough for sex to begin with.
Priligy® / Dapoxetine has been approved for premature ejaculation in several European countries with more expected to approve it soon. Some of the countries where it is approved are Sweden, Germany, Spain, Portugal, Finland, Austria, Italy, sources say that it is now available in the UK and other countries both in Europe and other continents are expected to soon have it available. However at the time of this writing the FDA has not yet approved it for the United States. It currently is in phase three trial investigations and testing but expect to hear something soon regarding its possibility in the US.
Premature ejaculation although not a dangerous or necessarily unhealthy condition, can cause disappointment, irritation, embarrassing as well as a relationship barrier to both partners. Numbers worldwide pin this problem somewhere around thirty percent but it is a little difficult to quantify as most men do not want to talk about it and it is hard to exclusively define. Some men who normally would not be under the premature ejaculation banner may from time to time in their life experience times of it. This can be brought on from over excitement or forms of anxiety.
Treating PE can be accomplished through various exercises performed along with mental imagery and other psychological practices but now there is a medical way to fight this issue. If you live in a country where Dapoxetine / Priligy® if available and you are interested in trying it, we would suggest you visit your doctor for their view of you taking it as well as any concerns or questions.
F.A.Q. (Frequently Asked Questions)
Composed below are some questions some people may have regarding Dapoxetine / Priligy®
Q) What are the side effects of this medication?
A) Side effects can be, but not limited to, nausea, dizziness, diarrhea, headache, tiredness. But these are not necessarily what you will experience, some experience all, some or none and to different degrees, but mostly mild to moderate. Always consult your doctor or pharmacist if others appear or if you have any questions what so ever.
Q) I am ready take a SSRI for depression, can I take this?
A) Generally No, Dapoxetine / Priligy ® should not be taken if you are on any other SSRI drug or drugs with serotonergic effects such as migraine drugs. Also do not take if you have heart problems or are dehydrated. Talk to your doctor.
Q) Can I drink Alcohol and take this medication?
A) No, you should not have this drug with alcohol. This can be dangerous.
Q) How often can I take this?
A) If you have been approved to take it, it generally should only be taken once in a 24 hour period.
Q) Are there age limits with this?
A) You should not use this product if you are under the age of 18 or over 64. Some exceptions may be made by your doctor.
Q) Can one take a drug such as Viagra or Cialis or Levitra (a PDE5 inhibitor) with this?
A) Studies show that these can be taken together. But always talk to your doctor as there could be other reasons not for someone to combine any medications together.
resource:http://www.dapoxetinepills.com/
Although this article refers to men staring at the tube, watching Dancing with the Stars (right) and driving in a car for more than 23 hours a week, this probably affects those that sit in from of their computers at home searching the web, chatting or talking to friends on Facebook.
In 1982, researchers affiliated with the Cooper Institute in Dallas surveyed a large group of well-educated, affluent men. The researchers were interested in the men’s exercise habits, but they also asked, almost incidentally, about their indolence. Specifically, they inquired about how many hours each day the men spent watching television or sitting in a car. (This was before you could do both at once.) Over the years, the survey’s main results were used to reinforce a growing body of science about the health benefits of regular exercise.
But the information about the amount of time the men spent being inactive remained largely unexplored. Recently, however, scientists from the University of South Carolina and the Pennington Biomedical Research Center in Baton Rouge, La., parsed the full data. In a study published in May in the journal Medicine and Science in Sports and Exercise, they reported that, to no one’s surprise, the men who sat the most had the greatest risk of heart problems. Men who spent more than 23 hours a week watching TV and sitting in their cars (as passengers or as drivers) had a 64 percent greater chance of dying from heart disease than those who sat for 11 hours a week or less. What was unexpected was that many of the men who sat long hours and developed heart problems also exercised. Quite a few of them said they did so regularly and led active lifestyles. The men worked out, then sat in cars and in front of televisions for hours, and their risk of heart disease soared, despite the exercise. Their workouts did not counteract the ill effects of sitting.
Most of us have heard that sitting is unhealthy. But many of us also have discounted the warnings, since we spend our lunch hours conscientiously visiting the gym. We consider ourselves sufficiently active. But then we drive back to the office, settle at our desks and sit for the rest of the day. We are, in a phrase adopted by physiologists, ‘‘active couch potatoes.’’
The amount of time that most Americans spend being inactive has risen steadily in recent decades. A 2009 editorial in the British Journal of Sports Medicine reported that, on average, adults spend more than nine hours a day in oxymoronic ‘‘sedentary activities.’’ For studies like these, scientists categorize activities by the number of METs they demand. A MET, or metabolic equivalent of task, is a measure of energy, with one MET being the amount of energy you burn lying down for one minute. Sedentary behaviors demand one to one and a half METs, or very little exertion.
Decades ago, before the advent of computers, plasma TVs and Roombas, people spent more time completing ‘‘light-intensity activities,’’ which require between one and a half and three METs. Most ‘‘home activities,’’ like mopping, cooking and changing light bulbs, demand between two and three METs. (One exception is ‘‘butchering animals,’’ a six-MET activity, according to a bogglingly comprehensive compilation from 2000 of the METs associated with different activities.) Nowadays, few of us accumulate much light-intensity activity. We’ve replaced those hours with sitting.
The physiological consequences are only slowly being untangled. In a number of recent animal studies, when rats or mice were not allowed to amble normally around in their cages, they rapidly developed unhealthy cellular changes in their muscles. The animals showed signs of insulin resistance and had higher levels of fatty acids in their blood. Scientists believe the changes are caused by a lack of muscular contractions. If you sit for long hours, you experience no ‘‘isometric contraction of the antigravity (postural) muscles,’’ according to an overview of the consequences of inactivity published this month in Exercise and Sports Sciences Reviews. Your muscles, unused for hours at a time, change in subtle fashion, and as a result, your risk for heart disease, diabetes and other diseases can rise.
Regular workout sessions do not appear to fully undo the effects of prolonged sitting. ‘‘There seem to be different pathways’’ involved in the beneficial physiological effects of exercising and the deleterious impacts of sitting, says Tatiana Warren, a graduate student in exercise science at the University of South Carolina and the lead author of the study of men who sat too much. ‘‘One does not undo the other,’’ she says.
You can, however, ameliorate the dangers of inactivity with several easy steps — actual steps. ‘‘Look for ways to decrease physical inactivity,’’ Ms. Warren says, beyond 30-minute bouts of jogging or structured exercise. Stand up. Pace around your office. Get off the couch and grab a mop or change a light bulb the next time you watch ‘‘Dancing With the Stars.’’
resource: http://well.blogs.nytimes.com/2010/07/14/phys-ed-the-men-who-stare-at-screens/?apage=1
Baldness is probably the one thing that causes men more anxiety than anything else in their life. Now, scientists believe they may have found a new way to reverse baldness and treat conditions like alopecia.
Scientists have identified stem cells or master cells in the hair follicles of mice. They found that these cells grow into hair follicles and produce hair when transplanted into skin. George Cotsarelis, Assistant Professor of dermatology from the University of Pennsylvania, said that the study could lead to new ways of treating hair loss in humans through drugs or surgery.
"This may lead to a new type of tissue engineering for treating baldness - for example, isolating hair follicle stem cells from the scalp and reconstituting hair follicles in bald areas," Dr Cotsarelis said. "I can't predict the future but this type of research certainly opens new avenues for developing new treatments for baldness."
The study, published in the journal Nature Biotechnology, isolated the stem cells within the bulbous follicle at the base of a hair shaft. Sometimes these follicles go into a permanent resting phase, halting hair regeneration. When the researchers transplanted the stem cells into the skin of other mice, hair follicles began to re-grow within four weeks.
"Now that we can isolate stem cells involved in hair growth, we can develop targets for manipulating hair growth," Dr Cotsarelis said.
Receding hairlines and the arrival of the bald patch are feared by men around the globe. Hair may start to disappear from the temples and the crown of the head at any time. For some men this process starts as early as the later teenage years, for most it happens in the late 20s and early 30s. Initially it may just be a little thinning that's noticed. Then, the absence of hair allows more of the scalp to become visible.
Some men are not troubled by this process at all. Others, however, suffer great emotional distress associated with a lack of self-confidence and sometimes depression.
In male pattern baldness, which is hereditary, the hair is usually lost at the temples and the crown. This happens because an over-sensitivity of the hair follicle to normal levels of testosterone switches the hair loss gene on. Not every hair follicle has this gene which is why some hair falls out whilst other hair doesn't. Other causes of hair-loss that are usually reversible include; iron deficiency anaemia; under-active thyroid; fungal scalp infection; some prescribed medicines; and stress.
Scientists have long-suspected that hair follicles contained stem cells. However, it has proved difficult to isolate these cells in humans. This latest study raises hopes that they can now track these genes and identify stem cells in human hair follicles. "Ultimately, these findings provide potential targets for the treatment of hair loss and other disorders of skin and hair," the researchers wrote.
While the discovery could lead to new treatments for baldness and conditions like alopecia, the researchers believe it may also help burn victims. "One problem with a burn is that the wound is never covered with hair follicles," said Dr Cotsarelis. "These cells have that capability so if we can isolate them and seed them onto a wound we can constitute skin that is more normal than currently possible."
Hair multiplication
Stem cells and dermal papilla cells have been discovered in hair follicles and some researchers predict research on these follicular cells may lead to successes in treating baldness through hair multiplication (HM), also called hair cloning.
HM is being developed by ARI (Aderans Research Institute, a Japanese owned company in the USA).
In 2008, Intercytex, a company in Manchester (UK), announced positive results of a Phase II trial for a form of cloning hair follicles from the back of the neck, multiplying them and then reimplanting the cells into the scalp. The initial testing resulted in at least two thirds of male patients regrowing hair. As of 2009, the company estimates this treatment will take "a number of years to complete" Phase III trials before it can go to market.
However, after failing to achieve subsequent success in their trials, the company announced discontinuation of its hair multiplication project in January 2010 with intention to sell off its assets and research.[30] In March 25, 2010 Aderans Research Institute Inc. (ARI) announced it acquired key technology assets from Regenerative Medicine Assets Limited (formerly
In May 2007, U.S. company Follica Inc, announced they have licensed technology from the University of Pennsylvania which can regenerate hair follicles by reawakening genes which were once active only in the embryo stage of human development. Skin apparently can be brought back to this embryonic state when a wound is healing. Hair growth was discovered in the skin wounds of mice when Wnt proteins were introduced to the site. Development of a human treatment is expected to take several years.
resource: http://en.wikipedia.org/wiki/Baldness_treatments
In other news:
New Clinically Proven Treatment for Hair Loss Now Available in the United Kingdom and Europe
2010-07-02 23:56:54 - Eucapil, a relatively new treatment for male pattern baldness is now available in the UK and the rest of Europe. The product has been clinically proven to help treat hair loss, in a 12 month double blind, placebo controlled University study.
Eucapil is a relatively new product on the market, to treat the age old problem of male pattern baldness. It has been scientifically proven to be effective in double blind controlled clinical studies.
Menspharma, the exclusive UK distributor of Eucapil, whose website can be found at
www.menspharma.com have carried out two user surveys and can now report the following extremely encouraging results:
In the most recent study involving over 150 random users, the following results were reported by current Eucapil users; 62% of respondents fell into the 25 to 40 age range. 73% of respondents reported a complete cessation or slowing down of their hair loss within 1 to 6 months of use and perhaps most significant of all 48% of respondents reported varying levels of regrowth of hair in the vertex (crown) and temple areas.
As the product is topically applied (i.e. directly to the scalp) and is not absorbed by the body, it therefore has the added bonus of none of the unwanted side effects associated with other clinically proven treatments for hair loss currently available, which are absorbed by the body and can cause a variety of unwanted side effects.
In summary, Eucapil is a safe, approved, tried and tested, clinically proven treatment to help fight male pattern baldness
resource: http://www.pr-inside.com/new-clinically-proven-treatment-for-r1982885.htm
How and where is Eucapil® approved?
Eucapil® is approved as a cosmetic hair care agent for topical use in the Czech and Slovak Republics and can therefore be employed as such in all other EU countries.
Is Eucapil® approved in the U.S., Japan or Canada?
Eucapil® is not yet approved for sale in these countries. Depending on the particular regulations , cosmetics can be brought in by travelers or imported for personal use. Please consult your customs agency.
Where is it possible to buy Eucapil®?
Eucapil® can be purchased in selected pharmacies throughout the Czech and Slovak Republics or on-line at www.menspharma.com and www.eucapil-shop.eu which will expedited to other EU and other countries.
Will Eucapil® be effective if applied to the hair?
Eucapil® was designed to be applied directly to the scalp in order to enter the hair follicles thus affecting the hair loss and promoting strengthening of the hair stem. Application of Eucapil® to the hair only would thus not be effective.
How does Eucapil® work?
The mechanism of Eucapil® action is explained in the introduction, Hair Loss .
Will Eucapil® affect hair on other regions of the body?
Eucapil® applied to the scalp skin will promote hair growth only in that region. Effect of Eucapil® formulated as gel has been studied in facial hirsutism (excessive growth of hair in women) where the male hormone promotes hair growth (in contradistinction to the scalp).
Will Eucapil® affect the body systemically?
Daily application of Eucapil® has not affected the normal levels of testosterone in the body. This was demonstrated in a 12-month clinical trial in young males. (see the articles).
What will happen if Eucapil® gets into my eyes?
If Eucapil® runs into the eyes during application, the eyes should be immediately flushed with copious amounts of water. The studies indicate that Eucapil® has a low irritation potential and any ocular irritancy observed in safety studies proved to be completely reversible. As noted in our package insert, we recommend applying Eucapil® with the head tilted back to facilitate its distribution and to prevent exposure to the eyes.
Is the isopropyl alcohol formulation of Eucapil® safe?
Isopropyl alcohol, also known by its common name rubbing alcohol, is used in many cosmetic products, is listed in the Pharmacopeias as a useful topical vehicle which has low hazard potential to human health.
When is the best time to apply Eucapil®?
Although it is recommended that Eucapil® be applied at bedtime, it can be used any time, provided that the scalp is dry.
Will shampoo affect Eucapil®?
No, but for maximum effectiveness Eucapil® should not be washed away soon after the application. It can be applied after shampooing, making certain first that the scalp is completely dry.
What about Eucapil® and sun exposure?
While using Eucapil®, it is not recommended to expose the scalp to strong sun: sunburn, the scalp inflammatory reaction, might be potentiated.
Can Eucapil® be used with other topical hair loss treatments?
We hear that some customers are using Eucapil® concurrently with other hair loss treatments. The effectiveness or safety of Eucapil® in combinations has not yet been studied. Eucapil® may not be applied simultaneously with water based products.
Can women use Eucapil®?
Eucapil® is safe for treatment of hair loss in women. As a precaution it should not be used by women who are pregnant, breast-feeding or planning to become pregnant.
What side effects can I expect from Eucapil®?
To this day, no side effects have been observed from daily topical use of Eucapil® when used as described in the product insert. Patients with a propensity toward seborrheic dermatitis (scalp irritation) may experience a flare-up of their condition attributable to the topical rubbing alcohol component of Eucapil® . These events proved reversible upon cessation of use.
How long must I use Eucapil®?
Eucapil® should be used daily, as long as necessary. We cannot predict individual responsiveness.
Can I increase the dose of Eucapil®?
There is no evidence that increasing the daily dose of Eucapil® would increase its effectiveness.
Can I use Eucapil® twice daily?
The current studies indicate that once a day application of Eucapil® is sufficient.
Can Eucapil® be used with all colors and types of hair?
Yes, but we have occasionally seen that white hair can acquire a light yellowish hue which nevertheless can readily be washed away.
Is Eucapil® still effective if people shampoo their hair daily? Is it absolutely necessary that the user shampoos no more than once or twice a week?
First, one would generally assume that applying anything on the scalp and then washing it right away would probably be counter-productive. Second, Eucapil® was designed to degrade in the water environment. This is a security feature. Eucapil® is resorbed into the skin only, there is no evidence for systemic resorption and any side-effects:. Eucapil® was designed to decompose should it for whatever reason enter the body, (such as accidental ingestion). Therefore, it is important not to apply fluridil to the scalp when wet. Third, shampoos remove the skin and hair fat effectively and thus signal to the sebaceous glands to work harder: a vicious circle is thus established. We hear from Eucapil® users who have reduced their shampooing frequency, washed hair with warm water and some soap only, or used the so-called “dry shampoos” that although it took many weeks before the scalp glands´ activity returned to normal, it eventually did.
What is the topical/local half-life before Eucapil® is absorbed/distributed into the circulation?
Eucapil® is designed not to be resorbed systemically and to act only topically on the scalp skin. Not even traces of fluridil ( measured at the extremely low level of 5 nanograms /ml) or its decomposition products were found in the blood or urine of the subjects who used the product over an extended period of time. Fluridil is also designed to degrade in an aqueous environment, such as if accidentally swallowed. The topical half-life (on the skin) cannot be determined as it depends on the individual humidity and overall condition of the skin.
How soon can we expect the release of Eucapil® in France and other European countries?
The substance fluridil has been registered via France in the EU, and approval of Eucapil® as a cosmetic hair-care agent has been granted in the Czech and Slovak Republics. Eucapil® can therefore be utilized in other EU countries. Several other countries have also approved the product as a cosmetic agent.
Can patients use minoxidil or perhaps other water based topicals in combination with Eucapil®? If people can use minoxidil in combination with fluridil, do they apply minoxidil before, after or simultaneously with Eucapil®?
We have not studied the combination of Eucapil® and minoxidil. If users of Eucapil® decide to explore such combination, it would be reasonable – for the reasons of stability stated above – that minoxidil be applied first and then Eucapil® after, when the scalp is completely dry, surely not at the same time. It should be considered that most formulations of minoxidil contain water which can cause Eucapil® to decompose .
How would you compare the effectiveness of Eucapil® to that of finasteride, dutasteride and minoxidil, respectively?
Eucapil® has not yet been tested in a comparative study with the above media. The data in the Drug Development Research can be compared to the published data for these and other products.
DISCLAIMER
Interpharma Praha, a.s., the manufacturer of fluridil and Eucapil®, and Biophysica, Inc., the holder of patent rights to fluridil, are not responsible for the correctness, completeness, reliability or usefulness of the information provided below. Viewing these questions does not constitute a consultation or the rendering of advice. While there may be information below related to certain medical conditions and their treatment, should a medical condition exist, promptly see your own physician or health care provider. Please consult the labeling of this cosmetic product before using it.
